Genomic Analysis of a Mycobacterium Bovisbacillus Calmette-Guerin Strain Isolated from an Adult Patient with Pulmonary Tuberculosis

文献类型： 外文期刊

第一作者： Li, Xuming

作者： Li, Xuming;Chen, Liping;Cao, Jun;Liu, Siguo;Li, Xuming;He, Jin;Guo, Aizhen;Zhu, Yongqiang;Wang, Rui;Lv, Xinyan;Zheng, Huajun;Yu, Xia;Huang, Hairong;Zheng, Huajun

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2015 年 10 卷 4 期

页码：

收录情况： SCI

摘要： For years, bacillus Calmette-Guerin (BCG) has served as the unique vaccine against tuberculosis and has generally been regarded as safe. However, a clinical strain labeled 3281 that was isolated from a TB patient was identified to be BCG. Via the combination of next-generation sequencing (NGS) and comparative genomic analysis, unique 3281 genetic characteristics were revealed. A region containing the dnaA and dnaN genes that is closely related to the initial chromosome replication was found to repeat three times on the BCG Pasteur-specific tandem duplication region DU1. Due to the minimum number of epitopes in BCG strains, 3281 was inferred to have a high possibility for immune evasion. Additionally, variations in the virulence genes and predictions for potential virulence factors were analyzed. Overall, we report a pathogen that has never previously been thought to be pathogenic and initial insights that are focused on the genetic characteristics of virulent BCG.

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