Up-regulation of NLRC5 and NF-kappa B signaling pathway in carrier chickens challenged with Salmonella enterica Serovar Pullorum at different persistence periods

文献类型： 外文期刊

第一作者： Liu, Xiangping

作者： Liu, Xiangping;Sheng, Zhongwei;Dou, Xinhong;Wang, Kehua;Ma, Teng;Wang, Hongzhi;Li, Zhiteng;Pan, Zhiming;Chang, Guobin;Chen, Guohong

作者机构：

关键词： Chicken;S. Pullorum;Immune performance;SNPs;Candidate gene;Expression

期刊名称：INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS （ 影响因子：1.918； 五年影响因子：1.406 ）

ISSN： 0301-1208

年卷期： 2015 年 52 卷 2 期

页码：

收录情况： SCI

摘要： The immune performance, SNPs and expression levels of candidate genes (IL1-beta, Nramp1, TLR4, MyD88, NF-kappa B and NLRC5) were analyzed in carrier chickens of a Chinese indigenous breed infected with Salmonella enterica Serovar Pullorum at different persistence periods (12, 19 and 24 weeks of age). Carrier birds at 19 weeks of age presented significant difference in most immune parameters, as compared to carriers at 12 and 24 weeks of age, while no significant difference in most immune parameters was observed between carriers at 12 and 24 weeks of age. The genotype distributions of IL1-beta and TLR4 presented significant differences between carriers and healthy birds. The expression levels of most candidate genes in carriers at 19 weeks of age were significantly higher than that in carriers at 12, 24 weeks of age and healthy birds and reached 1% level of significance between carriers at 19 weeks of age and healthy birds. The expression patterns of all genes, but IL-1 beta and NLRC5 between carriers at 12 and 24 weeks of age in all tissues were similar. Compared with carriers at 12 weeks of age, IL1-beta was significantly down-regulated, but NLRC5 was significantly up-regulated in carriers at 24 weeks of age. Our study demonstrated that immune performance of carrier birds was severely impaired at age of sexual maturation and NLRC5 might play as a negative mediator of NF-kappa B pathway involved in immune response to asymptomatic infection by S. Pullorum. The TLR4/MyD88/NF-kappa B pathway might be suitable for study on S. Pullorum infection in Chinese indigenous breeds.

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