Genome-wide Mapping Reveals Conservation of Promoter DNA Methylation Following Chicken Domestication

文献类型： 外文期刊

第一作者： Li, Qinghe

作者： Li, Qinghe;Wang, Yuanyuan;Li, Qinghe;Wang, Yuanyuan;Hu, Xiaoxiang;Zhao, Yaofeng;Li, Ning;Li, Qinghe;Wang, Yuanyuan;Hu, Xiaoxiang;Zhao, Yaofeng;Li, Ning

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2015 年 5 卷

页码：

收录情况： SCI

摘要： It is well-known that environment influences DNA methylation, however, the extent of heritable DNA methylation variation following animal domestication remains largely unknown. Using meDIP-chip we mapped the promoter methylomes for 23,316 genes in muscle tissues of ancestral and domestic chickens. We systematically examined the variation of promoter DNA methylation in terms of different breeds, differentially expressed genes, SNPs and genes undergo genetic selection sweeps. While considerable changes in DNA sequence and gene expression programs were prevalent, we found that the inter-strain DNA methylation patterns were highly conserved in promoter region between the wild and domestic chicken breeds. Our data suggests a global preservation of DNA methylation between the wild and domestic chicken breeds in either a genome-wide or locus-specific scale in chick muscle tissues.

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