Serine Proteases of Parasitic Helminths

文献类型： 外文期刊

第一作者： Yang, Yong

作者： Yang, Yong;Wen, Yun jun;Cheng, Shi Peng;Yang, Yong;Vallee, Isabelle;Boireau, Pascal;Cai, Ya Nan;Liu, Ming Yuan;Liu, Ming Yuan

作者机构：

关键词： Serine protease;biological function;parasitic helminth;nematode;trematode;cestode

期刊名称：KOREAN JOURNAL OF PARASITOLOGY （ 影响因子：1.341； 五年影响因子：1.669 ）

ISSN： 0023-4001

年卷期： 2015 年 53 卷 1 期

页码：

收录情况： SCI

摘要： Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development, and fertilization. A number of serine proteases have been identified in parasitic helminths that have putative roles in parasite development and nutrition, host tissues and cell invasion, anticoagulation, and immune evasion. In this review, we described the serine proteases that have been identified in parasitic helminths, including nematodes (Trichinella spiralis, T.pseudospiralis, Trichuris muris, Anisakis simplex, Ascaris suum, Onchocerca volvulus, O. lienalis, Brugia malayi, Ancylostoma caninum, and Steinernema carpocapsae), cestodes (Spirometra mansoni, Echinococcus granulosus, and Schistocephalus solidus), and trematodes (Fasciola hepatica, F. gigantica, and Schistosoma mansoni). Moreover, the possible biological functions of these serine proteases in the endogenous biological phenomena of these parasites and in the host-parasite interaction were also discussed.

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