Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish

文献类型： 外文期刊

第一作者： Ding, Qianwen

作者： Ding, Qianwen;Li, Yu;Liu, Hongliang;Hao, Qiang;Zhou, Zhigang;Ding, Qianwen;Ringo, Einar;Olsen, Rolf Erik;Zhang, Zhen;Yang, Yalin;Ran, Chao;Clarke, Jihong Liu

作者机构：

期刊名称：ISCIENCE （ 影响因子：5.458； 五年影响因子：5.458 ）

ISSN：

年卷期： 2021 年 24 卷 6 期

页码：

收录情况： SCI

摘要： Propionate and propionyl-CoA accumulation have been associated with the development of mitochondrial dysfunction. In this study, we show that propionate induces intestinal damage in zebrafish when fed a high-fat diet (HFD). The intestinal damage was associated with oxidative stress owing to compromised superoxide dismutase 2 (Sod2) activity. Global lysine propionylation analysis of the intestinal samples showed that Sod2 was propionylated at lysine 132 (K132), and further biochemical assays demonstrated that K132 propionylation suppressed Sod2 activity. In addition, sirtuin 3 (Sirt3) played an important role in regulating Sod2 activity via modulating de-propionylation. Finally, we revealed that intestinal oxidative stress resulting from Sod2 propionylation contributed to compositional change of gut microbiota. Collectively, our results in this study show that there is a link between Sod2 propionylation and oxidative stress in zebrafish intestines and highlight the potential mechanism of intestinal problems associated with high propionate levels.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序