Endothelial Cells Regulate Cardiac Myocyte Reorganisation Through beta 1-Integrin Signalling

文献类型： 外文期刊

第一作者： Zhang, Yu

作者： Zhang, Yu;Wei, Renyue;Ma, Jing;Zhao, Yanhua;Liu, Zhonghua;Li, Hai;Zhang, Yu;Li, Hai;Lian, Zhengxing

作者机构：

关键词： Endothelial cell;Cardiac myocyte;beta 1-integrin;Myocardial infarction

期刊名称：CELLULAR PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：5.5； 五年影响因子：4.354 ）

ISSN： 1015-8987

年卷期： 2015 年 35 卷 5 期

页码：

收录情况： SCI

摘要： Background: In normal hearts, capillaries are densely distributed throughout the myocardial tissue, and the cross-talk between myocytes and capillary endothelial cells plays a pivotal role in regulating cardiac development, maturation and function. Although previous studies have suggested a role for the endothelium in the organisation of nearby cardiomyocytes, the underlying mechanism has yet to be illustrated. Methods and Results: Using a transwell coculture system, we studied the paracrine effect of endothelial cells on cardiomyocytes and found that the regulation of cardiomyocyte spatial reorganisation and cytoskeletal dynamics by endothelial cells was coupled with beta 1-integrin induction. To determine the role of beta 1-integrin in this process, we preincubated myocytes with a beta 1-integrin function-blocking antibody before coculture. beta 1-integrin blockage abolished myocyte chemotactic activity and inhibited microtubule extension and stress fibre assembly. We further evaluated the therapeutic potential of combined endothelial cell-cardiac myocyte transplantation against ischemic cardiomyopathy in an acute myocardial infarction (AMI) mouse model. The results showed that myocytes and endothelial cells synergistically promoted ischemic myocardial repair, as evidenced by the robust engraftment and migration of implanted cells within the infarcted area, as well as the stimulation of angiogenesis, the attenuation of scar tissue and the improvement of cardiac function. Conclusion: Our study demonstrated the necessity of beta 1-integrin in the interactions between cardiomyocytes and endothelial cells and presented a novel combined transplantation approach that might hold promise for treating ischemic cardiomyopathy.

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