The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells

文献类型： 外文期刊

第一作者： Li, Yining

作者： Li, Yining;Zhang, Cao;Gong, Yu;Xie, Yixi;Cao, Yi;Liu, Liangliang;Cao, Yi

作者机构：

关键词： Baicalein (Ba);baicalin (Bn);ZnO nanoparticle;interaction;Caco-2 cells

期刊名称：TOXICOLOGY MECHANISMS AND METHODS （ 影响因子：2.987； 五年影响因子：2.78 ）

ISSN： 1537-6516

年卷期： 2018 年 28 卷 3 期

页码：

收录情况： SCI

摘要： Recent study suggested that the presence of phytochemicals in food could interact with nanoparticles (NPs) and consequently reduce the toxicity of NPs, which has been attributed to the antioxidant properties of phytochemicals. In this study, we investigated the interactions between ZnO NPs and two flavonoids baicalein (Ba) or baicalin (Bn) as well as the influence of the interactions on the toxicity of ZnO NPs to Caco-2 cells. The antioxidant properties of Ba and Bn were confirmed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, with Ba being stronger. However, the presence of Ba or Bn did not significantly affect cytotoxicity, intracellular superoxide or release of inflammatory cytokines of Caco-2 cells after ZnO NP exposure. When Ba was present, the cellular viability of Caco-2 cells after exposure to ZnO NPs was slightly increased, associated with a modest decrease of intracellular Zn ions, but these effects were not statistically different. Ba was more effective than Bn at changing the hydrodynamic sizes, Zeta potential and UV-Vis spectra of ZnO NPs, which indicated that Ba might increase the colloidal stability of NPs. Taken together, the results of the present study indicated that the anti-oxidative phytochemical Ba might only modestly protected Caco-2 cells from the exposure to ZnO NPs associated with an insignificant reduction of the accumulation of intracellular Zn ions. These results also indicated that when assessing the combined effects of NPs and phytochemicals to cells lining gastrointestinal tract, it might be necessary to evaluate the changes of colloidal stability of NPs altered by phytochemicals.

分类号：

  • 相关文献

[1]Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles. Zhang, Cao,Li, Yining,Gong, Yu,Xie, Yixi,Cao, Yi,Liu, Liangliang,Cao, Yi. 2018

[2]Assessment of Iron Bioavailability in Ten Kinds of Chinese Wheat Flours Using an in vitro Digestion/Caco-2 cell Model. Lei Ji,Chen Xiang Gui,Lei Ji,Zhang Ming Qiu,Bai Lin,Huang Cheng Yu,Zhang Yong,Ivan, Ortiz Monasterio. 2012

[3]The presence of palmitate affected the colloidal stability of ZnO NPs but not the toxicity to Caco-2 cells. Gong, Yu,Li, Juan,Cao, Yi,Liu, Liangliang,Cao, Yi. 2017

[4]Effect of Cr(VI) on Fe(III) reduction in three paddy soils from the Hani terrace field at high altitude. Li, Xiao-min,Liu, Tong-xu,Li, Fang-bai,Zhang, Nai-ming,Ren, Guo,Li, Xiao-min,Li, Yong-tao. 2012

[5]Overexpression of OsCIPK30 Enhances Plant Tolerance to Rice stripe virus. Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun,Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun. 2017

[6]Which Factors Determine Metal Accumulation in Agricultural Soils in the Severely Human-Coupled Ecosystem?. Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang,Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang. 2016

[7]Mouse hepatitis virus nucleocapsid protein interacts receptor for activated C kinase1, and regulates AKT signal pathway. Zhang, Pengju,Wu, Xinghong,Wang, Jun,Long, Miao. 2017

[8]Functional Genomic Analysis of Aspergillus flavus Interacting with Resistant and Susceptible Peanut. Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Dai, Xiaofeng,Guo, Wei. 2016

[9]Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase. Wang, Qian,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui. 2013

[10]F(0)ATP synthase b-chain of Litopenaeus vannamei involved in White Spot Syndrome Virus infection. Li, Qian,Liu, Qing-hui,Huang, Jie,Li, Qian. 2013

[11]Study on Interaction between Coomassie Brilliant Blue G-250 and Bovine Serum Albumin by Fluorescence Spectroscopy and Molecular Modeling. Wang Yong-gang,Yang Guang-rui,Leng Fei-fan,Ma Jian-zhong,Ma Xue-qing,Wang Xiao-li. 2017

[12]Genomic prediction with epistasis models: on the marker-coding-dependent performance of the extended GBLUP and properties of the categorical epistasis model (CE). Martini, Johannes W. R.,Gao, Ning,Cardoso, Diercles F.,Erbe, Malena,Simianer, Henner,Gao, Ning,Cardoso, Diercles F.,Cardoso, Diercles F.,Erbe, Malena,Cantet, Rodolfo J. C.. 2017

[13]Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes. Li, Pengpeng,Zhang, Muhan,Zou, Ye,Sun, Zhilan,Sun, Chong,Geng, Zhiming,Xu, Weimin,Wang, Daoying. 2018

[14]Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. Li, Wenliang,Mao, Li,Yang, Leilei,Hao, Fei,Zhang, Wenwen,Jiang, Jieyuan,Cao, Yongguo,Zhou, Bin,Han, Linxiao,Lin, Tao. 2017

[15]Metabolomics Investigation of an Association of Induced Features and Corresponding Fungus during the Co-culture of Trametes versicolor and Ganoderma applanatum. Xu, Xiao-Yan,Shen, Xiao-Ting,Yuan, Xiao-Jie,Zhu, Li-Ping,Yang, Song,Zhou, Yuan-Ming,Fan, Huan,Du, Feng-Yu,Sadilek, Martin,Yang, Jie,Qiao, Bin,Yang, Song. 2018

[16]Effects of Bacillus thuringiensis toxin Cry1Ac and Beauveria bassiana on Asiatic corn borer (Lepidoptera : Crambidae). Ma, Xiao-Mu,Liu, Xiao-Xia,Ning, Xia,Zhang, Bo,Han, Fei,Guan, Xiu-Min,Zhang, Qing-Wen,Tan, Yun-Feng. 2008

[17]Nine facultative endosymbionts in aphids. A review. Hatt, Severin,He, Kanglai,Chen, Julian,Wang, Zhenying,Guo, Jianqing,Hatt, Severin,Francis, Frederic,Guo, Jianqing,Hatt, Severin. 2017

[18]Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration. Chen, Yin Bin,Wang, Yu Fang,Hou, Wei,Wang, Ying Ping,Xiao, Sheng Yuan,Wang, Jia,Zheng, Si Wen,Zheng, Pei He,Xiao, Sheng Yuan,Fu, Yang Yang. 2017

[19]The Interactions between ZnO Nanoparticles (NPs) and alpha-Linolenic Acid (LNA) Complexed to BSA Did Not Influence the Toxicity of ZnO NPs on HepG2 Cells. Zhou, Yiwei,Fang, Xin,Xiao, Aiping,Liu, Liangliang,Cao, Yi,Zhou, Yiwei,Fang, Xin,Gong, Yu,Xie, Yixi,Cao, Yi. 2017

[20]The interaction of soybean reticulon homology domain protein (GmRHP) with Soybean mosaic virus encoded P3 contributes to the viral infection. Cui, Xiaoyan,Lu, Lu,Wang, Ying,Yuan, Xingxing,Chen, Xin,Wang, Ying. 2018

作者其他论文 更多>>

微信小程序