Pseudo template molecularly imprinted polymer for determination of 14 kind of beta-agonists in animal urine by ultra-high-performance liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Suo, Decheng

作者： Suo, Decheng;Wang, Ruiguo;Wang, Peilong;Fan, Xia;Su, Xiaoou

作者机构：

关键词： beta-Agonists;Pseudo template molecularly imprinted materials;Ultraperformance liquid chromatography tandem mass spectrometry;Pharmaceutical analysis

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

ISSN： 0021-9673

年卷期： 2017 年 1526 卷

页码：

收录情况： SCI

摘要： A pseudo template molecularly imprinted polymer (MIP) for selective extraction of beta-agonists was prepared using 4-hydroxyphenethyl alcohol as pseudo template molecule, methyl acrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. Selectivity and adsorption capacity of prepared MIP were studied in detail. MIP selectively adsorbed 14 types of beta-agonists. Advantages of the prepared polymer include non-template leakage in purification of target analytes and cheap cost. MIP was used to purify beta-agonists in urine samples. The developed method was combined with ultra-performance liquid chromatography-tandem mass spectrometry. In optimum conditions, recoveries of the developed method ranged from 84.2% to 109.8% with low coefficients of variation at below 15%. Limits of detection and quantification for 14 target beta-agonists in urine samples reached below 0.05 ng/mL and 0.1 ng/mL, respectively. The developed method based on MIP enrichment and purification were successfully applied to analysis of target analytes in 50 actual urine samples. (C) 2017 Elsevier B.V. All rights reserved.

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