Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo

文献类型： 外文期刊

第一作者： Xu, Jinfang

作者： Xu, Jinfang;Qian, Ping;Wu, Qunfeng;Liu, Shasha;Fan, Wenchun;Wang, Rong;Zhang, Huawei;Chen, Huanchun;Li, Xiangmin;Xu, Jinfang;Qian, Ping;Wu, Qunfeng;Liu, Shasha;Fan, Wenchun;Wang, Rong;Zhang, Huawei;Chen, Huanchun;Li, Xiangmin;Zhang, Keshan

作者机构：

关键词： Antiviral activity;Foot-and-mouth disease virus;Swine IFITM3;Viral attachment

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：5.97； 五年影响因子：5.801 ）

ISSN： 0166-3542

年卷期： 2014 年 109 卷

页码：

收录情况： SCI

摘要： The interferon-induced transmembrane protein 3 (IFITM3) is a widely expressed potent antiviral effector of the host innate immune system. It restricts a diverse group of pathogenic, enveloped viruses, by interfering with endosomal fusion. In this report, the swine IFITM3 (sIFITM3) gene was cloned. It shares the functionally conserved CD225 domain and multiple critical amino acid residues (Y19, F74, F77, R86 and Y98) with its human ortholog, which are essential for antiviral activity. Ectopic expression of sIFITM3 significantly inhibited non-enveloped foot-and-mouth disease virus (FMDV) infection in BHK-21 cells. Furthermore, sIFITM3 blocked FMDV infection at early steps in the virus life cycle by disrupting viral attachment to the host cell surface. Importantly, inoculation of 2-day-old suckling mice with a plasmid expressing sIFITM3 conferred protection against lethal challenge with FMDV. These results suggest that sIFITM3 is a promising antiviral agent and that can safeguard the host from infection with FMDV. (C) 2014 Elsevier B.V. All rights reserved.

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