Porcine Coronin 1A Contributes to Nuclear Factor-Kappa B (NF-kappa B) Inactivation during Haemophilus parasuis Infection

文献类型： 外文期刊

第一作者： Liu, Chong

作者： Liu, Chong;Zhang, Hengling;Cheng, Shuang;Chen, Pin;He, Qigai;Wang, Yang;Charreyre, Catherine;Audonnet, Jean Christophe

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2014 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Haemophilus parasuis (H. parasuis) is the etiological agent of porcine polyserositis and arthritis (Glasser's disease) characterized by fibrinous polyserositis, meningitis and polyarthritis, causing severe economic losses to the swine industry. Currently, the molecular basis of this infection is largely unkonwn. Coronin 1A (Coro1A) plays important roles in host against bacterial infection, yet little is known about porcine Coro1A. In this study, we investigated the molecular characterization of porcine Coro1A, revealing that porcine Coro1A was widely expressed in different tissues. Coro1A could be induced by lipopolysaccharide (LPS), polyinosinic acid-polycytidylic acid [poly (I: C)] and H. parasuis in porcine kidney-15 (PK-15) cells. Functional analyses revealed that porcine Coro1A suppressed the NF-kappa B activation during H. parasuis infection by inhibiting the degradation of I kappa B alpha and nuclear translocation of p65. Overexpression of porcine Coro1A inhibited the transcription of NF-kappa B-mediated downstream genes [Interleukin-6 (IL-6), Interleukin-8 (IL-8) and COX-2] through down-regulation of NF-kappa B. The results indicated that porcine Coro1A is an important immunity related gene that helps to inhibit NF-kappa B activation during H. parasuis infection.

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