Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-( alkynyloxy)pyrimidine derivatives as potential pigment biosynthesis inhibitors

文献类型: 外文期刊

第一作者: Ma, Hong-Ju

作者: Ma, Hong-Ju;Zhang, Jian-Hua;Xia, Xiang-Dong;Xu, Meng-Han;Li, Jian-Hong;Ning, Jun

作者机构:

关键词: pigment biosynthesis inhibitors;pyrimidine;chlorophyll;bleaching herbicidal activity

期刊名称:PEST MANAGEMENT SCIENCE ( 影响因子:4.845; 五年影响因子:4.674 )

ISSN: 1526-498X

年卷期: 2014 年 70 卷 6 期

页码:

收录情况: SCI

摘要: BACKGROUNDWith the objective of finding novel valuable herbicidal candidates, a series of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives were synthesised and their herbicide activities were evaluated in vivo. RESULTSThe results showed that many target compounds expressed bleaching activities. Among these, compound 5h showed the best bleaching activity to gramineous weeds, being able to produce the highest inhibition of chlorophyll level in seedlings of Pennisetum alopecuroides L. (IC50 = 3.48mg L-1). Moreover, compound 5h expressed good selective toxicity between gramineous P. alopecuroides L. and broadleaf plant Brassica campestris L. CONCLUSIONSThe present work demonstrates that pyrimidine derivatives containing pyrazole can be used as potential lead compounds for developing novel pigment biosynthesis inhibitors. (c) 2013 Society of Chemical Industry

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