Effects of sub-chronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats

文献类型： 外文期刊

第一作者： Zhu, Y. Z.

作者： Zhu, Y. Z.;Fu, Yang;Wang, J.;Song, M.;Li, M.;Li, Y. F.;Zhu, Y. Z.;Miao, L. G.;Sun, H.

作者机构：

关键词： Aluminum chloride;Rat;Spermatogenesis;Testicular enzymes

期刊名称：LIFE SCIENCES （ 影响因子：5.037； 五年影响因子：4.689 ）

ISSN： 0024-3205

年卷期： 2014 年 102 卷 1 期

页码：

收录情况： SCI

摘要： Aims: The aim of this study was to determine the effects of sub-chronic aluminum chloride (A1Cl(3)) on spermatogenesis and testicular enzymatic activity in male rats. Main methods: Forty Wistar male rats were randomly divided into four groups: control group (CG, 0), low-dose group (LG, 64.18 mg/kg BW AlCl3), mid-dose group (MG, 12836 mg/kg BW AlCl3) and high-dose group (HG, 256.72 mg/kg BWAICl(3)).The rats were orally administered with AlCl3 for 120 days. At the end of the experiment, the contents of Al, Fe, Cu and Zn, the enzyme activities of testicular acid phosphatase (ACP), succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), lactate dehydrogenase isoenzyme (LDH-x), the sperm count and the sperm malformation rate were examined. Key findings: The results showed that the Al and Cu contents, sperm count and the enzyme activities of testicular ACP, SDH, LDH and LDH-x decreased, while the Zn and Fe contents and sperm malformation rate increased in AlCl3-treated rats. Significance: It suggests that sub-chronic AlCl3 disorders the balance of trace element and decreases the spermatogenesis and the activities of testicular enzymes, indicating that AlCl3 has adverse effect on the testicular function in male rats. (C) 2014 Elsevier Inc. All rights reserved.

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