Selenium Inhibits LPS-Induced Pro-inflammatory Gene Expression by Modulating MAPK and NF-kappa B Signaling Pathways in Mouse Mammary Epithelial Cells in Primary Culture

文献类型: 外文期刊

第一作者: Zhang, Wen

作者: Zhang, Wen;Wang, Tiancheng;Jiang, Haichao;Guo, Mengyao;Zhou, Ershun;Sun, Yong;Yang, Zhengtao;Cao, Yongguo;Zhang, Naisheng;Zhang, Runxiang;Xu, Shiwen

作者机构:

关键词: selenium;mouse mammary epithelial cell;anti-inflammation;nuclear factor-kappa B;mitogen-activated protein kinase

期刊名称:INFLAMMATION ( 影响因子:4.092; 五年影响因子:3.923 )

ISSN: 0360-3997

年卷期: 2014 年 37 卷 2 期

页码:

收录情况: SCI

摘要: Mastitis is characterized by an inflammation of the mammary gland of dairy animals and humans; this condition is one of the major causes of economic losses in dairy industries. Selenium (Se), a biological trace element, modulates the functions of many regulatory proteins in signal transduction and provides advantages for animals with inflammatory diseases, including mastitis. The current study aimed to assess the protective effects and the active mechanism of Na2SeO3 against lipopolysaccharide (LPS)-induced inflammation in mouse mammary epithelial cells (MMECs). Our results showed that LPS-induced expressions of cyclooxygenase-2 and tumor necrosis factor-alpha significantly decreased after Se was supplemented to Se-deficient MMECs. Na2SeO3 also suppressed LPS-induced nuclear factor-kappa B activation, inhibitory kappa B degradation, and ERK, JNK, and P38 phosphorylation in a dose-dependent manner. These results suggested that Se functions as an anti-inflammatory agent in mastitis.

分类号:

  • 相关文献

[1]The role of Ca2+ mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Dai, Bin,Liu, Ming,Zhang, Yuanshu,Xu, Yuanyuan,Miao, Jinfeng,Zhang, Jinqiu,Lu, Jinye,Yin, Yulong.

[2]Mechanisms of suppression of interferon production by porcine reproductive and respiratory syndrome virus. Zhu, L.,Zhou, Y.,Tong, G.. 2012

[3]Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acid on CCl4-induced damage in precision-cut liver slices from Jian carp (Cyprinus carpio var. jian) through inhibition of the nf-kB pathway. Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun,Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun.

[4]Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappa B signalling pathway. Cheng, Anwei,Han, Caijing,Sun, Jinyue,Chen, Xiangyan,Fang, Xixiu,Wan, Fachun,Cheng, Anwei,Han, Caijing,Sun, Jinyue,Chen, Xiangyan.

[5]Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-kappa B/bFGF signaling. Mei, Wen-Li,Dai, Hao-Fu,Guo, Jun-Li,Zheng, Shao-Jiang,Li, Yue-Nan,Hao, Xin-Bao,Li, Tian-Fa,Xia, Li-Ping,Huang, Feng-Ying,Kong, Yue-Qiong,He, Qi-Yi,Yang, Kun,Tan, Guang-Hong,Jie, Wei. 2012

[6]Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells. Lim, Yourim,Park, Ji-Won,Kwon, Ok-Kyoung,Lee, Jae-Won,Lee, Han-Sol,Ahn, Kyung-Seop,Lim, Yourim,Lee, Han-Sol,Han, Sang-Bae,Lee, Sangwoo,Choi, Sangho,Li, Wanyi,Jin, Hang. 2018

[7]Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. Liu, Shuqing,Jia, Hong,Hou, Shaohua,Zhang, Gaimei,Xin, Ting,Yuan, Weifeng,Guo, Xiaoyu,Li, Ming,Wu, Jing,Zhu, Hongfei,Li, Hegang,Li, Hegang,Gao, Xintao. 2014

[8]Cloning and analysis of the soybean MEKK gene. Sha, A. -H.,Ba, H. -P.,Shan, Z. -H.,Chen, H. -F.,Chen, S. -L.,Qiu, D. -Z.,Zhou, X. -A.,Sha, A. -H.,Chen, Y. -H.. 2015

[9]The Role of Radical Burst in Plant Defense Responses to Necrotrophic Fungi. Kulye, Mahesh S.,Liu Hua,Qiu De-wen. 2012

[10]Isolation and characterization of an oilseed rape MAP kinase BnMPK3 involved in diverse environmental stresses. Yu, SW,Zhang, LD,Zuo, KJ,Tang, DQ,Tang, KX.

[11]Expression Profiling of Mitogen-Activated Protein Kinase Genes Reveals Their Evolutionary and Functional Diversity in Different Rubber Tree (Hevea brasiliensis) Cultivars. Jin, Xiang,Zhu, Liping,Yao, Qi,Meng, Xueru,Ding, Guohua,Wang, Dan,Tong, Zheng,Wang, Xuchu,Jin, Xiang,Zhu, Liping,Xie, Quanliang,Tao, Chengcheng,Yu, Li,Li, Hongbin,Wang, Xuchu. 2017

[12]Identification of six mitogen-activated protein kinase (MAPK) genes in banana (Musa acuminata L. AAA group, cv. Cavendish) under infection of Fusarium Oxysporum f. sp cubense Tropical Race 4. Wang, Zhuo,Jia, Caihong,Li, Jianpin,Xu, Biyu,Jin, Zhiqiang,Jin, Zhiqiang.

[13]Inhibitory effect of Malvidin on TNF-alpha-induced inflammatory response in endothelial cells. Huang, Wu-Yang,Wang, Jian,Li, Chun-Yang,Wang, Jian,Liu, Ya-Mei,Zheng, Qi-Sheng. 2014

[14]Evaluation of Antibacterial and Anti-inflammatory Activities of Less Polar Ginsenosides Produced from Polar Ginsenosides by Heat-transformation. Wang, Lijun,Yang, Xiushi,Yu, Xiaona,Yao, Yang,Ren, Guixing,Wang, Lijun,Yang, Xiushi,Yu, Xiaona.

[15]Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Guo, Xia,Chen, Dan-Dan,Peng, Kai-Song,Cui, Zheng-Wei,Zhang, Xu-Jie,Li, Shun,Zhang, Yong-An,Guo, Xia,Peng, Kai-Song,Cui, Zheng-Wei,Zhang, Xu-Jie.

[16]Porcine glucagon-like peptide-2 microspheres ameliorate inflammation in lipopolysaccharide-challenged weaning piglets. Wu, J.,Qi, K. K.,Xu, Z. W..

[17]Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages. Cheng, Anwei,Tian, Yaoqi,Cheng, Anwei,Yan, Haiqing,Han, Caijing,Wang, Wenliang,Chen, Xiangyan,Tian, Yaoqi.

[18]Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum. Zhang, Kai,Zhao, Xiangli,Dernedde, Jens,Fan, Hua,Liu, Yanfang,Tang, Qingjiu,Zhang, Jingsong. 2018

[19]Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-kappa B activation. Zhao, Zhanzhong,Tang, Xiangfang,Zhang, Minhong,Hou, Shaohua,Yuan, Weifeng,Zhang, Hongfu,Shi, Lijun,Jia, Hong,Liang, Lin,Zhao, Zhanzhong,Zhao, Xinghui,Fu, Ling,Chen, Wei,Zhang, Weijian,Lai, Zhi,Gao, Junfeng,Zhang, Keyu. 2014

[20]Structural and anti-inflammatory characterization of a novel neutral polysaccharide from North American ginseng (Panax quinquefolius). Wang, Lijun,Yu, Xiaona,Yang, Xiushi,Yao, Yang,Ren, Guixing,Wang, Lijun,Li, Yi,Lui, Edmund Man King.

作者其他论文 更多>>