Ractopamine Residues in Urine, Plasma and Hair of Cattle During and After Treatment

文献类型： 外文期刊

第一作者： Tang, Chaohua

作者： Tang, Chaohua;Zhang, Junmin;Li, Lijun;Zhao, Qingyu;Bu, Dengpan

作者机构：

期刊名称：JOURNAL OF ANALYTICAL TOXICOLOGY （ 影响因子：3.367； 五年影响因子：3.21 ）

ISSN： 0146-4760

年卷期： 2014 年 38 卷 3 期

页码：

收录情况： SCI

摘要： The objective of this study was to investigate ractopamine residues in urine, plasma and hair of cattle during and after treatment. Three cattle (body weight 620 6.2 kg) were administered ractopamine (2.01 mg/kg body weight) into the rumen for 5 consecutive days. Ractopamine concentrations in samples were determined by an ultra-performance liquid chromatographytandem mass spectrometry (UPLCMS-MS) method. The concentrations of parent ractopamine in urine were 1,631.1 ng/mL on withdrawal day 0 and 8.3 ng/mL on withdrawal day 14. After hydrolysis of its conjugates, ractopamine concentration ranged from 11,796.7 ng/mL (withdrawal day 0) to 39.7 ng/mL (withdrawal day 14). In plasma, parent ractopamine and its conjugates were below the limits of quantification (LOQ 0.2 ng/mL) on withdrawal days 5 and 7. Accumulation of ractopamine in black and white hair was 124.6 and 78.1 ng/g, respectively, on withdrawal day 0, and 226.7 and 165.6 ng/g, respectively, on withdrawal day 14. This study demonstrated the rapid elimination and high bioavailability of ractopamine in urine and plasma in cattle. However, accumulation of ractopamine in cattles hair is high and persistent, so hair can be used as the target matrix for monitoring ractopamine abuse in ruminants.

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