Multi-Omics Analysis of Mammary Metabolic Changes in Dairy Cows Exposed to Hypoxia

文献类型： 外文期刊

第一作者： Kong, Zhiwei

作者： Kong, Zhiwei;He, Qinghua;Kong, Zhiwei;Kong, Zhiwei;Zheng, Yuzhong;Li, Bin;Zhou, Chuanshe;Tan, Zhiliang

作者机构：

关键词： metabonomics; lipidomics; hypoxia; lipid metabolism; dairy cow

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）

ISSN：

年卷期： 2021 年 8 卷

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收录情况： SCI

摘要： Hypoxia exposure can cause a series of physiological and biochemical reactions in the organism and cells. Our previous studies found the milk fat rate increased significantly in hypoxic dairy cows, however, its specific metabolic mechanism is unclear. In this experiment, we explored and verified the mechanism of hypoxia adaptation based on the apparent and omics results of animal experiments and in vitro cell model. The results revealed that hypoxia exposure was associated with the elevation of AGPAT2-mediated glycerophospholipid metabolism. These intracellular metabolic disorders consequently led to the lipid disorders associated with apoptosis. Our findings update the existing understanding of increased adaptability of dairy cows exposure to hypoxia at the metabolic level.

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