Leonurus japonicus Houtt.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine

文献类型： 外文期刊

第一作者： Shang, Xiaofei

作者： Shang, Xiaofei;Pan, Hu;Wang, Xuezhi;He, Hua;Li, Maoxing

作者机构：

关键词： Leonurus japonicus;Women's diseases;Leonurine;Stachydrine;Effects on the uterus;Cardioprotective activity

期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：4.36； 五年影响因子：4.488 ）

ISSN： 0378-8741

年卷期： 2014 年 152 卷 1 期

页码：

收录情况： SCI

摘要： Ethnopharmacological relevance: Leonurus japonicas Houtt. (Labiatae), commonly called Chinese motherwort (tyFq), is an herbaceous flowering plant native to Asia. For thousands of years in China, the aerial part of Leonurus japonicus has been used to treat menoxenia, dysmenorrhea, amenorrhea, lochia, edema of the body, oliguresis, sores, ulcerations and other diseases in women. Now, Leonurus japonicas is listed in the Pharmacopoeia of the People's Republic of China. The present paper reviewed the ethnopharmacology, phytochemistry, biological actions and toxicology of Leonurus japonicus. Materials and methods: Information on Leonurus japonicus was gathered via the Internet (using Elsevier, ACS, Medline Plus, CNIG, VIP, Web of Science, Google Scholar and Baidu Scholar) and libraries. Results: Approximately 140 chemical compounds have been isolated from Leonurus japonicus, and the major components have been determined to be alkaloids, diterpenes and flavones. Among these active compounds, the effects of leonurine and stachydrine have been widely investigated. The primary active components in Leonurus japonicas possess wide pharmacological actions, such as effects on the uterus as well as cardioprotective, anti-oxidative, neuroprotective and anti-cancer activities. Conclusions: Modern pharmacological studies have demonstrated that Leonurus japonicas has marked bioactivities, especially on the uterus and as a cardioprotective agent. These activities are related to its traditional use and provide prospects for the development of novel drugs, therapeutics and health care products for women,. However, the toxicity of Leonurus japonicas will require further study, and the nomenclature for Leonurus japonicas will require additional clarification. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.

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