Associations of single nucleotide polymorphisms in candidate genes with the polled trait in Datong domestic yaks

文献类型： 外文期刊

第一作者： Liu, W. B.

作者： Liu, W. B.;Liu, J.;Liang, C. N.;Guo, X.;Bao, P. J.;Chu, M.;Ding, X. Z.;Wang, H. B.;Zhu, X. S.;Yan, P.

作者机构：

关键词： association study;domestic yak;haplotype;high-resolution melting;polledness;SNP

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

ISSN： 0268-9146

年卷期： 2014 年 45 卷 1 期

页码：

收录情况： SCI

摘要： The domestic yak (Bos grunniens) is an iconic symbol of animal husbandry at high altitudes. Yaks exhibit unique external characteristics including long hair and large horns. However, hornless yaks can be found in different breeds and different populations. The hornless trait is also known as polled, and the POLL locus has been fine-mapped to chromosome 1 in cattle (Bos taurus), although the underlying genetic basis of the polled trait is still unclear in the yak. Thus, we performed an association study to identify the genetic polymorphisms responsible for the polled trait in the yak. Fifty polled Datong domestic yaks and 51 horned individuals were selected randomly from a huge herd and were used as the case and control groups respectively for the association analysis. Twelve genes located in the candidate region of the POLL locus in cattle were used as references to detect DNA polymorphisms related to yak polledness, which were analyzed by sequencing and a high-resolution melting test. We applied Fisher's exact test and haplotype analysis to show that a 147-kb segment that included three protein-coding genes C1H21orf62, GCFC1 and SYNJ1 was the most likely location of the POLL mutation in domestic yaks.

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