Resiquimod and polyinosinic-polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine
文献类型: 外文期刊
第一作者: Zhou, Chun-Xue
作者: Zhou, Chun-Xue;Li, Dong;Chen, Ying-Li;Lu, Zeng-Jun;Sun, Pu;Cao, Yi-Mei;Bao, Hui-Fang;Fu, Yuan-Fang;Li, Ping-Hua;Bai, Xing-Wen;Xie, Bao-Xia;Liu, Zai-Xin
作者机构:
关键词: R848;Poly(I:C);Aluminum hydroxide;FMDV
期刊名称:BMC VETERINARY RESEARCH ( 影响因子:2.741; 五年影响因子:2.955 )
ISSN: 1746-6148
年卷期: 2014 年 10 卷
页码:
收录情况: SCI
摘要: Background: Toll-like receptor (TLR) agonists reportedly have potent antiviral and antitumor activities and may be a new kind of adjuvant for enhancing immune efficacy. Resiquimod (R848) is an imidazoquinoline compound with potent antiviral activity and functions through the TLR7/TLR8 MyD88-dependent signaling pathway. Polyinosinic-polycytidylic acid [poly(I:C)] is a synthetic analog of double-stranded RNA that induces the production of pro-inflammatory cytokines by the activation of NF-kappa B through TLR3. This study investigated the potential of R848 and poly(I:C) as an adjuvant 146S foot-and-mouth disease virus (FMDV) vaccine formulated with aluminum hydroxide (Al(OH)(3)). Results: Antibody titers to FMDV and CD8(+) T cells were markedly enhanced in mice immunized to 146S FMDV + Al(OH)(3) + R848 + poly(I:C) compared with mice immunized to FMDV + ISA206. IFN-gamma secretion substantially increased compared with IL-4 secretion by splenic T cells stimulated with FMDV antigens in vitro, suggesting that R848, poly(I:C), and with Al(OH)(3) together biased the immune response toward a Th1-type direction. Conclusions: These results indicated that the R848 and poly(I:C) together with Al(OH)(3) enhanced humoral and cellular immune responses to immunization with 146S FMDV antigens. Thus, this new vaccine formulation can be used for FMDV prevention.
分类号:
- 相关文献
作者其他论文 更多>>
-
Integrative omics analyses of tea (Camellia sinensis) under glufosinate stress reveal defense mechanisms: A trade-off with flavor loss
作者:Yu, Huan;Miao, Peijuan;Zhou, Chunran;Cheng, Haiyan;Dong, Qinyong;Pan, Canping;Li, Dong;Wu, Yangliu;Zhao, Yingjie;Liu, Zhusheng;Zhao, Yingjie;Zhou, Li
关键词:Tea; Glufosinate; Transcriptome; Metabolomic; Quality
-
Whole-genome analysis of the recombination and evolution of newly identified NADC30-like porcine reproductive and respiratory syndrome virus strains circulated in Gansu province of China in 2023
作者:Jiao, Shoude;Zhang, Jing;Wang, Jian;Ma, Xueqing;Li, Guoxiu;Li, Jiaoyang;Cui, Zhanding;Li, Dong;Li, Pinghua;Liu, Zaixin;Lu, Zengjun;Sun, Pu;Jiao, Shoude;Zhang, Jing;Wang, Jian;Ma, Xueqing;Li, Guoxiu;Li, Jiaoyang;Cui, Zhanding;Li, Dong;Li, Pinghua;Liu, Zaixin;Lu, Zengjun;Sun, Pu;Zeng, Qiaoying;Sun, Pu
关键词:porcine reproductive and respiratory syndrome virus; ORF5; NSP2; NADC30-like; recombination
-
Vocalization Pattern and Echolocation Signal Characteristics of Yangtze Finless Porpoise (Neophocaena asiaeorientalis asiaeorientalis) in Captivity
作者:Chen, Jia;Liang, Haiying;Liu, Kai;Lin, Danqing;Zhang, Jialu;Li, Dong;Ye, Kun;Lu, Wenfei;Liu, Kai
关键词:Yangtze finless porpoise; echolocation signal; behavioral state; diurnal variation; ambiguity function
-
A novel approach for estimating fractional cover of crops by correcting angular effect using radiative transfer models and UAV multi-angular spectral data
作者:Pan, Yuanyuan;Wu, Wenxuan;He, Jiaoyang;Zhu, Jie;Su, Xi;Li, Wanyu;Li, Dong;Yao, Xia;Cheng, Tao;Zhu, Yan;Cao, Weixing;Tian, Yongchao;Pan, Yuanyuan
关键词:Multi-FVC model; Multi-angle remote sensing; Soil background, PROSAIL; Gaussian process regression
-
Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
作者:Cao, Xueli;Li, Dong;Wang, Hao;Guan, Linlin;Wang, Yu;Feng, Yue;Xiao, Yu;Huiting, Erin;Fedorova, Iana;Bondy-Denomy, Joseph;Cao, Xujun;Cao, Xujun;Li, Lingyin;Cao, Xujun;Li, Lingyin;Cao, Xujun;Li, Lingyin;Ren, Jie;Bondy-Denomy, Joseph;Bondy-Denomy, Joseph
关键词:
-
High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1
作者:Cui, Zhanding;Liu, Jinlong;Wang, Tao;Sun, Pu;Wang, Jinlong;Li, Jiaoyang;Li, Guoxiu;Sun, Ying;Yin, Juanbin;Li, Kun;Zhao, Zhixun;Yuan, Hong;Bai, Xingwen;Ma, Xueqing;Li, Pinghua;Fu, Yuanfang;Bao, Huifang;Li, Dong;Zhang, Qiang;Liu, Zaixin;Cao, Yimei;Zhang, Jing;Lu, Zengjun;Xie, Chong;Wang, Jinlong;Qiu, Jicheng;Zhang, Ying;Li, Dengliang;Sun, Ying;Cao, Yimei;Zhang, Jing;Lu, Zengjun
关键词:
-
Infection by virulent w MelPop Wolbachia improves learning and memory capacity in Drosophila melanogaster
作者:Chen, Meng-Yan;Li, Dong;Wang, Zhi-Ning;Xu, Feng-Zhen;Feng, Yi-Wei;Yu, Qiong-Lin;Wang, Ying-Ying;Wang, Yu-Feng;Zhang, Shu;Zhang, Shu
关键词:Drosophila melanogaster; wMelPop; memory; RNA sequencing