Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan

文献类型： 外文期刊

第一作者： Li, Xinghai

作者： Li, Xinghai;Cui, Zining;Nishida, Yoshihiro;Cui, Zining

作者机构：

关键词： Synthesis;5-Phenyl-2-furan;Carvacrol and thymol derivatives;Antitumor activity;Antifungal activity

期刊名称：LETTERS IN DRUG DESIGN & DISCOVERY （ 影响因子：1.15； 五年影响因子：0.994 ）

ISSN： 1570-1808

年卷期： 2014 年 11 卷 7 期

页码：

收录情况： SCI

摘要： A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title compounds had a considerable effect on the selected fungi. Generally the bioactivity of the carvacrol and its derivatives were better than that of the thymol and its derivatives. The substituted groups on the ortho- and para-positions gave better activity than that of ones on the meta-position.

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