Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

文献类型： 外文期刊

第一作者： Wu LiZhen

作者： Wu LiZhen;Zhou LinKang;Gong JingYi;Li Peng;Wu LiZhen;Zhou LinKang;Gong JingYi;Li Peng;Chen Cheng;Xu Li;Ye Jing;Li De

作者机构：

关键词： Cidea;Fsp27;brown adipose tissue;white adipose tissue;lipid droplet fusion

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）

ISSN： 1674-7305

年卷期： 2014 年 57 卷 1 期

页码：

收录情况： SCI

摘要： Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes, fatty liver and cardiovascular diseases. The lipid droplet (LD) is an important subcellular organelle responsible for lipid storage. We previously observed that Fsp27, a member of the CIDE family proteins, is localized to LD-contact sites and promotes atypical LD fusion and growth. Cidea, a close homolog of Fsp27, is expressed at high levels in brown adipose tissue. However, the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown. Here, we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth. Next, we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype. In addition, Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold. Furthermore, we observed that the brown and white adipose tissues of Cidea/Fsp27 double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27 single deficient mice. Overall, these data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity.

分类号：

  • 相关文献

[1]Cold exposure induces the acquisition of brown adipocyte gene expression profiles in cattle inguinal fat normalized with a new set of reference genes for qRT-PCR. Cao, K. X.,Hao, D.,Wang, J.,Peng, W. W.,Yan, Y. J.,Chen, H.,Cao, H. X.,Sun, F..

[2]Pig has no uncoupling protein 1. Hou, Lianjie,Shi, Jia,Cao, Lingbo,Xu, Guli,Wang, Chong,Hu, Chingyuan.

[3]Cold adaptation in pigs depends on UCP3 in beige adipocytes. Lin, Jun,Ye, Rongcai,Dong, Meng,Jiang, Xiaoxiao,Jin, Wanzhu,Lin, Jun,Ye, Rongcai,Dong, Meng,Zheng, Qiantao,Jiang, Xiaoxiao,Cao, Chunwei,Zheng, Qiantao,Qin, Guosong,Zhao, Jianguo,Tao, Cong,Wang, Chao,Li, Kui,Wang, Yanfang,Yan, Changguo,Speakman, John R.,Jin, Wanzhu,Zhao, Jianguo.

[4]AMPK alpha 1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Zhao, Junxing,Du, Min,Zhao, Junxing,Yang, Qiyuan,Zhang, Lupei,Liang, Xingwei,Wang, Bo,Chen, Yanting,Du, Min,Sun, Xiaofei,Zhang, Lupei. 2017

[5]Changes in white and brown adipose tissue microRNA expression in cold-induced mice. Tao, Cong,Qi, Desheng,Tao, Cong,Huang, Shujuan,Wang, Yajun,Zhang, Yang,Wang, Yanfang,Li, Kui,Wei, Gang.

作者其他论文 更多>>

微信小程序