Effects of Reticuloendotheliosis Virus Infection on Cytokine Production in SPF Chickens

文献类型： 外文期刊

第一作者： Xue, Mei

作者： Xue, Mei;Shi, Xingming;Zhao, Yan;Cui, Hongyu;Hu, Shunlei;Wang, Yunfeng;Xue, Mei;Shi, Xingming;Zhao, Yan;Cui, Hongyu;Hu, Shunlei;Wang, Yunfeng;Cui, Xianlan

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2013 年 8 卷 12 期

页码：

收录情况： SCI

摘要： Infection with reticuloendotheliosis virus (REV), a gammaretrovirus in the Retroviridae family, can result in immunosuppression and subsequent increased susceptibility to secondary infections. The effects of REV infection on expression of mRNA for cytokine genes in chickens have not been completely elucidated. In this study, using multiplex branched DNA (bDNA) technology, we identified molecular mediators that participated in the regulation of the immune response during REV infection in chickens. Cytokine and chemokine mRNA expression levels were evaluated in the peripheral blood mononuclear cells (PBMCs). Expression levels of interleukin (IL)-4, IL-10, IL-13 and tumor necrosis factor (TNF)-alpha were significantly up-regulated while interferon (IFN)-alpha, IFN-beta, IFN-gamma, IL-1 beta square IL-2, IL-3, IL-15, IL-17F, IL-18 and colony-stimulating factor (CSF)-1 were markedly decreased in PBMCs at all stages of infection. Compared with controls, REV infected chickens showed greater expression levels of IL-8 in PBMCs 21 and 28 days post infection. In addition, REV regulates host immunity as a suppressor of T cell proliferative responses. The results in this study will help us to understand the host immune response to virus pathogens.

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