Expression profiling and single nucleotide polymorphism of mitogen-activated protein kinase kinase kinase 8 MAP3K8 in white muscovy ducks (Cairina moschata)

文献类型： 外文期刊

第一作者： Bello, Semiu Folaniyi

作者： Bello, Semiu Folaniyi;Xu, Haiping;Zhang, Dexiang;Zhang, Xiquan;Nie, Qinghua;Bello, Semiu Folaniyi;Xu, Haiping;Zhang, Xiquan;Nie, Qinghua;Bello, Semiu Folaniyi;Xu, Haiping;Zhang, Xiquan;Nie, Qinghua;Bello, Semiu Folaniyi;Bolaji, Umar-Faruq Olayinka;Aloryi, Kelvin Dodzi;Adeola, Adeniyi Charles;Gibril, Bahareldin Ali Abdalla;Popoola, Moshood Abiola;Popoola, Moshood Abiola;Zhu, Weijian;Zhang, Dexiang;Ji, Congliang;Nie, Qinghua

作者机构：

关键词： Egg production traits; Single nucleotide polymorphism; Expression level; White Muscovy duck; MAP3K8

期刊名称：GENE （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 0378-1119

年卷期： 2025 年 932 卷

页码：

收录情况： SCI

摘要： A previous study on ovarian and hypothalami transcriptome analysis in white Muscovy duck revealed that MAP3K8 gene participated in MAPK signaling pathway that influence egg production. Additionally, MAP3K8 was predicted as a target gene of miRNA-509-3p that promotes the secretion of oestradiol which is an important hormone in egg ovulation. This suggested that MAP3K8 might have a functional role in the reproductive performance "egg production" of white Muscovy ducks. Herein, we focused on expression level of MAP3K8 in reproductive and non-reproductive tissues of highest (HP) and lowest (LP) egg producing white Muscovy ducks and identified the polymorphism in MAP3K8 and its association with three egg production traits; Age at first egg (AFE), number of eggs at 300 days (N300D) and 59 weeks (N59W). The results of expression level indicated that mRNA of MAP3K8 was significantly (p <0.01) expressed in the oviduct than in the ovary and hypothalamus. Seven synonymous SNPs were detected, and association analysis showed that g.148303340 G>A and g.148290065 A>G were significantly (p < 0.05) associated with N300D and N59W. The results of this study might serve as molecular marker for marker-assisted selection of white Muscovy ducks for egg production.

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