Single dose pharmacokinetics of terbinafine in cats

文献类型： 外文期刊

第一作者： Wang, Ang

作者： Wang, Ang;Ding, Huanzhong;Gao, Yan;Zeng, Zhenling;Liu, Yiming

作者机构：

期刊名称：JOURNAL OF FELINE MEDICINE AND SURGERY （ 影响因子：2.015； 五年影响因子：2.218 ）

ISSN： 1098-612X

年卷期： 2012 年 14 卷 8 期

页码：

收录情况： SCI

摘要： The pharmacokinetics of terbinafine was studied in six healthy fasted cats following a single intravenous and oral administration at a dose of 10 mg/kg and 30 mg/kg, respectively, according to a two-period crossover design. Plasma terbinafine concentrations were determined using a reverse phase liquid chromatographic method. The pharmacokinetic parameters were calculated by non-compartmental analysis with WinNonlin 5.2.1 software. After intravenous administration, the terminal half-life and area under the curve from time 0 to infinity were 10.40 +/- 4.56 h, 15.20 +/- 3.61 h.mu g/ml, respectively. After oral dosing, the mean maximum concentration was 3.22 +/- 0.60 mu g/ml, reached at 1.33 +/- 0.41 h. The terminal half-life, area under the curve from time 0 to infinity and apparent volume of distribution were 8.01 +/- 3.46 h, 13.77 +/- 4.99 h.mu g/ml, 25.63 +/- 6.29 l/kg, respectively. The absolute bioavailability of terbinafine hydrochloride tablets after oral administration was 31.00 +/- 10.85%. Although bioavailability was low, excellent penetration at the site of infection and low minimum inhibitory concentrations values provided terbinafine with good efficacy against dermatophyte infections.

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