Recombinant canine distemper virus serves as bivalent live vaccine against rabies and canine distemper
文献类型: 外文期刊
第一作者: Feng, Na
作者: Feng, Na;Gao, Yuwei;Yang, Songtao;Xia, Xianzhu;Wang, Xijun;Ge, Jinying;Shuai, Lei;Peng, Liyan;Bu, Zhigao
作者机构:
关键词: Rabies;Canine distemper;Recombinant canine distemper virus;Vaccine
期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )
ISSN: 0264-410X
年卷期: 2012 年 30 卷 34 期
页码:
收录情况: SCI
摘要: Effective, safe, and affordable rabies vaccines are still being sought. Attenuated live vaccine has been widely used to protect carnivores from canine distemper. In this study, we generated a recombinant canine distemper virus (CDV) vaccine strain, rCDV-RVG, expressing the rabies virus glycoprotein (RVG) by using reverse genetics. The recombinant virus rCDV-RVG retained growth properties similar to those of vector CDV in Vero cell culture. Animal studies demonstrated that rCDV-RVG was safe in mice and dogs. Mice inoculated intracerebrally or intramuscularly with rCDV-RVG showed no apparent signs of disease and developed a strong rabies virus (RABV) neutralizing antibody response, which completely protected mice from challenge with a lethal dose of street virus. Canine studies showed that vaccination with rCDV-RVG induced strong and long-lasting virus neutralizing antibody responses to RABV and CDV. This is the first study demonstrating that recombinant CDV has the potential to serve as bivalent live vaccine against rabies and canine distemper in animals. (C) 2012 Elsevier Ltd. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
2023 International African Swine Fever Workshop: Critical Issues That Need to Be Addressed for ASF Control
作者:Wang, Lihua;Li, Yuzhen;Shi, Jishu;Ganges, Llilianne;Ganges, Llilianne;Dixon, Linda K.;Netherton, Christopher L.;Reis, Ana L.;Bu, Zhigao;Zhao, Dongming;Quang Lam Truong;Richt, Juergen A.;Jin, Meilin;Peng, Guiqing;Benarafa, Charaf;Summerfield, Artur;Benarafa, Charaf;Summerfield, Artur;Benarafa, Charaf;Summerfield, Artur;Weng, Changjiang;Han, Jun;Penrith, Mary-Louise;Mo, Yupeng;Su, Zhipeng;Dang Vu Hoang;Pogranichniy, Roman M.;Balaban-Oglan, David-Adrian;Balaban-Oglan, David-Adrian;Wang, Kewen;Cai, Xuepeng
关键词:African swine fever; workshop; platform; highlights; lessons; control; prevention
-
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway
作者:Ye, Guangqiang;Zhang, Zhaoxia;Liu, Xiaohong;Liu, Hongyang;Chen, Weiye;Feng, Chunying;Li, Jiangnan;Zhou, Qiongqiong;Zhao, Dongming;Zhang, Shuai;Chen, Hefeng;Bu, Zhigao;Huang, Li;Weng, Changjiang;Zhang, Zhaoxia;Li, Jiangnan;Huang, Li;Weng, Changjiang
关键词:ASFV; pH240R; ISGs; IFN; JAK-STAT; viral replication
-
A virus-like particle candidate vaccine based on CRISPR/Cas9 gene editing technology elicits broad-spectrum protection against SARS-CoV-2
作者:Wang, Weiqi;Xia, Xianzhu;Wang, Weiqi;Wang, Shen;Meng, Xianyong;Zhao, Yongkun;Li, Nan;Wang, Tiecheng;Feng, Na;Yan, Feihu;Xia, Xianzhu;Meng, Xianyong
关键词:CRISPR/Cas9; Canarypox-virus vector; Virus -like particle vaccine; Cross -neutralizing antibody; Cellular immunity; Toll -like receptor 4
-
Establishment of two serological methods for detecting IgG and neutralizing antibodies against Crimean-Congo hemorrhagic fever virus glycoprotein
作者:Wang, Qi;Xia, Xianzhu;Wang, Qi;Wang, Shen;Shi, Zhikang;Li, Zhengrong;Zhao, Yongkun;Feng, Na;Wang, Tiecheng;Yan, Feihu;Xia, Xianzhu;Li, Zhengrong
关键词:CCHFV; rGP; rVSV/CCHFV; ELISA and sVNT; specific antibodies and serological samples
-
Antiviral activity of theaflavins against Zika virus in vivo and in vitro
作者:Deng, Xiuwen;Sima, Mingwei;Yue, Donghui;Gao, Yuwei;Deng, Xiuwen;Lv, Chaoxiang;Wang, Tiecheng;Guo, Jin;Luo, Rongbo;Qi, Jing;Sima, Mingwei;Gao, Yuwei;Lv, Chaoxiang;Guo, Jin;Qi, Jing;Yue, Donghui
关键词:Theaflavin; Zika virus; Antiviral; Polyphenols; Natural active
-
The antibacterial and hemostatic curdlan hydrogel-loading epigallocatechin gallate for facilitating the infected wound healing
作者:Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Xia, Xianzhu;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Mo, Zhendong;Xia, Xianzhu;Zhao, Pingsen
关键词:Curdlan; Epigallocatechin gallate; Antibacterial; Infected wound healing
-
A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice
作者:Wang, Zhenfei;Sun, Weiyang;Li, Dongxu;Sun, Yue;Zhu, Menghan;Wang, Wenqi;Zhang, Yiming;Li, Entao;Yan, Feihu;Wang, Tiecheng;Feng, Na;Yang, Songtao;Xia, Xianzhu;Gao, Yuwei;Wang, Zhenfei;Li, Dongxu;Sun, Yue;Zhu, Menghan;Wang, Wenqi;Zhang, Yiming
关键词:SARS-CoV-2; Influenza virus -vector vaccine; Spike RBD; Intranasal vaccination; Mice