Differences in iNOS and Arginase Expression and Activity in the Macrophages of Rats Are Responsible for the Resistance against T. gondii Infection

文献类型： 外文期刊

第一作者： Li, Zhi

作者： Li, Zhi;Zhao, Zhi-Jun;Ren, Qing-Shi;Nie, Fang-Fang;Gao, Jiang-Mei;Gao, Xiao-Jie;Yang, Ting-Bao;Zhou, Wen-Liang;Lu, Fang-Li;Lun, Zhao-Rong;Li, Zhi;Zhao, Zhi-Jun;Ren, Qing-Shi;Nie, Fang-Fang;Gao, Jiang-Mei;Gao, Xiao-Jie;Yang, Ting-Bao;Zhou, Wen-Liang;Lu, Fang-Li;Lun, Zhao-Rong;Zhu, Xing-Quan;Lun, Zhao-Rong;Shen, Ji-Long;Wang, Yong;Chen, Xiao-Guang;Hide, Geoff;Lun, Zhao-Rong;Ayala, Francisco J.;Zhao, Zhi-Jun

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2012 年 7 卷 4 期

页码：

收录情况： SCI

摘要： Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a mystery as to why the peritoneal macrophages of rats are naturally resistant to T. gondii infection while those of mice are not. Here, we report that high expression levels and activity of inducible nitric oxide synthase (iNOS) and low levels of arginase-1 (Arg 1) activity in the peritoneal macrophages of rats are responsible for their resistance against T. gondii infection, due to high nitric oxide and low polyamines within these cells. The opposite situation was observed in the peritoneal macrophages of mice. This discovery of the opposing functions of iNOS and Arg 1 in rodent peritoneal macrophages may lead to a better understanding of the resistance mechanisms of mammals, particularly humans and livestock, against T. gondii and other intracellular pathogens.

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