Association of polymorphisms of beta-2-microglobulin gene (beta 2m) with milk IgG1 content in Chinese Holstein dairy COWS

文献类型: 外文期刊

第一作者: Wang, Jiaqi

作者: Wang, Jiaqi;Liu, Guanglei

作者机构:

关键词: Beta-2-microglobulin;Genotypes;Immunoglobulin G1;Milk

期刊名称:LIVESTOCK SCIENCE ( 影响因子:1.943; 五年影响因子:2.252 )

ISSN: 1871-1413

年卷期: 2012 年 143 卷 2-3 期

页码:

收录情况: SCI

摘要: Beta-2-microglobulin (beta 2m) is an integral component of the Fc receptor (FcRn) heterodimer which is involved in IgG transfer across mammary epithelial cells. The aim of this study was to estimate the frequency of alleles of beta 2m and the association of SNPs genotypes as well as haplotypes with milk IgG1 concentration and mass. Blood DNA from 189 Chinese Holstein daily cows was extracted, sequenced and genotyping was analyzed. Milk IgG1 concentrations from these cows were determined by ELISA and evaluated with respect to their beta 2m genotypes. The results showed that two single nucleotide polymorphisms (SNPs) and one insertion/deletion (indel) of two base pairs, assorted into four haplotypes, were identified. The genotypes and haplotypes of beta 2m were found to be correlated (P<0.05) with milk IgG1 concentration and mass. Dairy cows with homozygous deletion of beta 2m had the lowest milk IgG1 concentration and mass. These results indicate that beta 2m genotypes could serve as a marker to identify dairy cows with high IgG1 milk levels. (C) 2011 Elsevier B.V. All rights reserved.

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