Aptamer and sodium alginate decorated graphene oxide composite material with ion responsiveness for Low-density lipoprotein trapping

文献类型： 外文期刊

第一作者： Cao, Jianfang

作者： Cao, Jianfang;Liu, Yaobo;Wang, Weiting;Du, Pengfei;Ma, Yanli;Wang, Yuanshang;Jin, Linshi

作者机构：

关键词： Graphene oxide; Sodium alginate; Stimuli-responsive; Low-density lipoprotein; Separation

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：3.8； 五年影响因子：3.5 ）

ISSN： 0021-9673

年卷期： 2024 年 1731 卷

页码：

收录情况： SCI

摘要： The accumulation of excess Low-density lipoprotein (LDL) is strongly associated with the occurrence of heart failure, coronary artery disease and hypercholesterolaemia, and is a major factor in cardiovascular and cerebrovascular disease. Concerns about the ways to decrease LDL level have continuously arisen. In this study, an ionic stimulation-responsive composite (i.e., GO@Apt@SA) is prepared with modification of graphene oxide (GO) utilising LDL-aptamer (Apt) and sodium alginate (SA). The ion-responsive behaviour of GO@Apt@SA synergistically interacts with the specific recognition property of the aptamer, enabling adsorption of LDL with higher capacity and specificity. Under the optimal experimental conditions, the maximum adsorption capacity of GO@Apt@SA for LDL is 730.6 mu g mg(-1). Interestingly, the aptamer complementary chain could trigger the release of LDL with favourable elution efficiency, which competitively binds with LDL-specific aptamer to trigger LDL release. More importantly, GO@Apt@SA exhibits satisfactory adsorption performances for LDL in goat serum, meaning that the composite material and technology are available for the extraction of LDL from complex sample matrices.

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