Geometrical Stuidy on FMDV Genome Based on Z-Curve

文献类型： 外文期刊

第一作者： Tang, Hua

作者： Tang, Hua;Liu, Xin-Sheng;Fang, Yu-Zhen;Pan, Li;Zhang, Zong-Wang;Zhou, Peng;Lv, Jian-Liang;Jiang, Shou-Tian;Wang, Yong-Lu;Zhang, Yong-Guang

作者机构：

关键词： Z-curve;geometrical study;FMDV;mutation;homology analysis;China

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2012 年 11 卷 15 期

页码：

收录情况： SCI

摘要： The Z-curve is a geometrical tool for visualizing and comparing genomes. Since, the curve contains the information carried by the given sequence, DNA sequences could be analyzed systematically. In this study, the Foot and Mouth Disease Virus (FMDV) was analyzed by the Z-curve Method. This research that all serotypes FMDV have a close consaguinity but each has its own characteristic by contrast, the three South African serotypes have a much closer affinity. FMDV have three A + T-rich regions and two G + C-rich regions. The most variable regions of FMDV lie in protein coding areas. And the non-coding region is very conservative. O serotype FMDV is most variable compared with A and Asial serotype. These O serotype FMDV in buffalo and goat have a mutation trend. Compared with host, geographic location have a grater influence of FMDV mutation. The A serotype FMDV strains occurred in India after 2002 are more stable and have a closer phylogenetic relationships compared with the Asial strains which were prevalent before 2002. in general, Z-curve method shows a widely application prospect in the areas of life sciences. Such as gene sequence, molecular epidemiology, homology, evolution, phylogenetic relationships and genetic diversity analysis.

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