Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan

文献类型： 外文期刊

第一作者： Cui, Zi-Ning

作者： Cui, Zi-Ning;Ling, Yun;Yang, Xin-Ling;Shi, Yan-Xia;Li, Bao-Ju;Cui, Jing-Rong

作者机构：

关键词： 5-phenyl-2-furan;antifungal activity;antitumor activity;pyrazole and triazole derivatives;synthesis

期刊名称：CHEMICAL BIOLOGY & DRUG DESIGN （ 影响因子：2.817； 五年影响因子：2.631 ）

ISSN： 1747-0277

年卷期： 2012 年 79 卷 1 期

页码：

收录情况： SCI

摘要： A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.

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