Metabolomic analysis of alterations in lipid oxidation, carbohydrate and amino acid metabolism in dairy goats caused by exposure to Aflotoxin B1

文献类型： 外文期刊

第一作者： Cheng, Jianbo

作者： Cheng, Jianbo;Huang, Shuai;Fan, Caiyun;Cheng, Jianbo;Zheng, Nan;Zhang, Yangdong;Li, Songli;Wang, Jiaqi;Zheng, Nan;Zhang, Yangdong;Li, Songli;Wang, Jiaqi

作者机构：

关键词： Aflatoxin B1;metabolic;NMR;dairy goats

期刊名称：JOURNAL OF DAIRY RESEARCH （ 影响因子：1.904； 五年影响因子：2.019 ）

ISSN： 0022-0299

年卷期： 2017 年 84 卷 4 期

页码：

收录情况： SCI

摘要： The purposes of this study were to investigate the systemic and characteristic metabolites in the serum of dairy goats induced by aflatoxin B1 (AFB1) exposure and to further understand the endogenous metabolic alterations induced by it. A nuclear magnetic resonance (NMR)-based metabonomic approach was used to analyse the metabolic alterations in dairy goats that were induced by low doses of AFB1 (50 mu g/kg DM). We found that AFB1 exposure caused significant elevations of glucose, citrate, acetate, acetoacetate, betaine, and glycine yet caused reductions of lactate, ketone bodies (acetate, -hydroxybutyrate), amino acids (citrulline, leucine/isoleucine, valine, creatine) and cell membrane structures (choline, lipoprotein, N-acetyl glycoproteins) in the serum. These data indicated that AFB1 caused endogenous metabolic changes in various metabolic pathways, including cell membrane-associated metabolism, the tricarboxylic acid cycle, glycolysis, lipids, and amino acid metabolism. These findings provide both a comprehensive insight into the metabolic aspects of AFB1-induced adverse effects on dairy goats and a method for monitoring dairy animals exposed to low doses of AFB1.

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