BmNPV-miR-415 up-regulates the expression of TOR2 via Bmo-miR-5738

文献类型： 外文期刊

第一作者： Cao, Xueliang

作者： Cao, Xueliang;Xia, Dingguo;Qiu, Zhiyong;Shen, Xingjia;Guo, Xijie;Zhao, Qiaoling;Huang, Yong;Cao, Xueliang;Huang, Yong;Xia, Dingguo;Qiu, Zhiyong;Shen, Xingjia;Guo, Xijie;Zhao, Qiaoling

作者机构：

关键词： 3 ' UTR;MicroRNAs;Bombyx mori;BmNPV;TOR2

期刊名称：SAUDI JOURNAL OF BIOLOGICAL SCIENCES （ 影响因子：4.219； 五年影响因子：4.432 ）

ISSN： 1319-562X

年卷期： 2017 年 24 卷 7 期

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) have emerged as key players in host-pathogen interaction and many virus-encoded miRNAs have been identified (computationally and/or experimentally) in a variety of organisms. A novel Bombyx mori nucleopolyhedrosis virus (BmNPV)-encoded miRNA miR-415 was previously identified through high-throughput sequencing. In this study, a BmNPV-miR-415 expression vector was constructed and transfected into BmN cells. The differentially expressed protein target of rapamycin isoform 2 (TOR2) was observed through two-dimensional gel electrophoresis and mass spectrometry. Results showed that TOR2 is not directly a target gene of BmNPV-miR-415, but its expression is up-regulated by BmNPV-miR-415 via Bmo-miR-5738, which could be induced by BmNPV. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

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