Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice

文献类型: 外文期刊

第一作者: Gai, Weiwei

作者: Gai, Weiwei;Zhang, Weijiao;Qiu, Boning;Gai, Weiwei;Wang, Hualei;Zhao, Yongkun;Wang, Qi;Zhang, Weijiao;Feng, Na;Qiu, Boning;Chi, Hang;Li, Nan;Wang, Tiecheng;Gao, Yuwei;Yang, Songtao;Xia, Xianzhu;Zheng, Xuexing;Wang, Chong;Wang, Qi;Wong, Gary;Shan, Junjie;Shan, Junjie;Yang, Songtao;Xia, Xianzhu

作者机构:

关键词: Marburg virus;Virus-like particle;Adjuvant;Vaccine;Immune response

期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )

ISSN: 1743-422X

年卷期: 2017 年 14 卷

页码:

收录情况: SCI

摘要: Background: Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease. Methods: In this study, we generated MARV virus-like particles (VLPs) by co-expressing the glycoprotein (GP) and matrix protein (VP40) using the baculovirus expression system. MARV VLPs and three adjuvants, Poria cocos polysaccharide (PCP-II), poly(I:C) and aluminium hydroxide, were evaluated after intramuscular vaccination in mice. Results: Murine studies demonstrated that vaccination with the MARV VLPs induce neutralizing antibodies and cellar immune responses. MARV VLPs and the PCP-II adjuvant group resulted in high titres of MARV-specific antibodies, activated relatively higher numbers of B cells and T cells in peripheral blood mononuclear cells (PBMCs), and induced greater cytokine secretion from splenocytes than the other adjuvants. Conclusion: MARV VLPs with the PCP-II adjuvant may constitute an effective vaccination and PCP-II should be further investigated as a novel adjuvant.

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