Expression of glutathione S-transferase A1, a phase II drug-metabolizing enzyme in acute hepatic injury on mice

文献类型： 外文期刊

第一作者： Ma, Xin

作者： Ma, Xin;Liu, Fangping;Li, Minmin;Li, Zhi;Lin, Yuexia;Li, Rui;Chang, Yicong;Zhao, Changwei;Han, Qing;Zhou, Qiong;Zhao, Yulin;Wang, Dening;Li, Changwen;Liu, Jingli

作者机构：

关键词： glutathione S-transferase A1;acute hepatic injury;content;mRNA expression;antioxidant

期刊名称：EXPERIMENTAL AND THERAPEUTIC MEDICINE （ 影响因子：2.447； 五年影响因子：2.263 ）

ISSN： 1792-0981

年卷期： 2017 年 14 卷 4 期

页码：

收录情况： SCI

摘要： In the present study, three models of acute liver injury in mice were induced via the administration of CCl4 (35 mg/kg, 24 h), acetyl-para-aminophenol (APAP; 200 mg/kg, 12 h) and ethanol (14 ml/kg, 8 h) to study the effect of glutathione S-transferase A1 (GSTA1) on acute liver injury. The serum levels of alanine transaminase, aspartate transaminase and liver homogenate indicators (superoxide dismutase, glutathione and glutathione peroxidase) were significantly lower in model groups compared with the control group (P<0.01), whereas the liver homogenate indicator malondialdehyde was significantly increased (P<0.01). The expression of GSTA1 in liver was significantly decreased in the model groups compared with the control group (P<0.01). GSTA1 protein content was 3.8, 1.3 and 2.6 times lower in the CCl4, APAP and ethanol model groups, respectively. Furthermore, GSTA1 mRNA expression levels decreased by 4.9, 2.1 and 3.7 times in the CCl4, APAP and ethanol model groups, respectively. Among the three models, the injury induced by CCl4 was the most marked, followed by ethanol and finally APAP. These results suggest that GSTA1 may be released by the liver and serve as an antioxidant in the prevention of liver damage.

分类号：

  • 相关文献

[1]Glutathione S-transferase A1 (GSTA1) release, an early indicator of acute hepatic injury in mice. Liu, Fangping,Lin, Yuexia,Li, Zhi,Ma, Xin,Han, Qing,Liu, Yingshu,Zhou, Qiong,Li, Rui,Li, Jichang,Gao, Li,Liu, Jingli. 2014

[2]Root restriction affected anthocyanin composition and up-regulated the transcription of their biosynthetic genes during berry development in 'Summer Black' grape. He, Jianjun,Yu, Xiuming,Li, Jiefa,Zhang, Caixi,Xu, Wenping,Wang, Shiping,Bai, Yang,Bai, Xianjin,Cao, Xiongjun. 2013

[3]Near-Infrared Reflectance Spectroscopy Analytic Models Established for the Crude Protein and Crude Fiber of Alfalfa Property. Zhang Yue-xue,Li Yan,Hao Ruo-chao,Tang Feng-lan,Han Wei-bo,Liu Jie-lin,Shang Chen. 2009

[4]Preliminary Investigation of the Amount, the Molecular Weight and the Activity of Polysaccharides from Chaenomeles Speciosa Fruits in Ethanol Fractional Precipitation. Tian Bing-mei,Xie Xiao-mei,Shen Pan-pan,Yang Mo,Zhang Sheng-long,Xie Xiao-mei,Tang Qing-jiu. 2015

[5]EFFECTS OF ORGANIC FERTILIZER INPUT ON HEAVY METAL CONTENT AND SPECIATION IN VEGETABLE AND SOIL. Han, Yaning,Hao, Yi,Rui, Yukiu,Liu, Liming,Rui, Mengmeng,Tang, Xinlian,Rui, Yukiu,Cao, Weidong,Cao, Weidong. 2016

[6]Comparative Analysis of Headspace Volatiles of Chinese Rosa rugosa. Liu, Ping,Zhao, Lan-Yong,Feng, Li-Guo,Chen, Chen,Sheng, Li-Xia,Tao, Jun,Su, Jia-Le. 2010

[7]Antioxidant activities and contents of polyphenol oxidase substrates from pericarp tissues of litchi fruit. Jiang, Yueming,Wei, Xiaoyi,Shi, Jinyu,Yi, Chun,Sun, Jian,Jiang, Yueming,Shi, John,Xue, Sophia Jun.

[8]mRNA Expression of Glutathione S-Transferase Pi (GSTP1) under Heat Stress and Association of Genotypes with Heat Tolerance Ability in Holstein. Lai, Song-Jia,Li, Qiu-Ling,Wang, Chang-Fa,Wang, Hong-Mei,Zhong, Ji-Feng. 2011

[9]Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3. Liu, X.,Wang, L. G.,Zhang, L. C.,Yan, H.,Zhao, K. B.,Liang, J.,Li, N.,Pu, L.,Zhang, T.,Wang, L. X.. 2016

[10]Sequence analysis of a putative goose RIG-I gene. Li, Guoqin,Li, Jinjun,Tian, Yong,Wang, Deqian,Shen, Junda,Tao, Zhengrong,Xu, Jian,Lu, Lizhi. 2012

[11]Molecular characterization, expression, polymorphism of NR5A2 and its relationship with litter size in Hu sheep. Li, Y. X.,Zhang, J.,Qian, Y.,Meng, C. H.,Wang, H. L.,Zhong, S.,Cao, S. X.,Li, Q. F.,Li, Y. X.,Zhang, J.,Qian, Y.,Meng, C. H.,Wang, H. L.,Zhong, S.,Cao, S. X.,Tao, X. J.. 2015

[12]Genetic effect of an A/G polymorphism in the HSP70 gene on thermotolerance in chicken. Chen, Z. Y.,Zhang, W. W.,Gan, J. K.,Kong, L. N.,Zhang, X. Q.,Zhang, D. X.,Luo, Q. B.,Chen, Z. Y.,Zhang, W. W.,Gan, J. K.,Kong, L. N.,Zhang, X. Q.,Zhang, D. X.,Luo, Q. B.. 2016

[13]Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Wang, Yanhua,Wu, Shenggan,Chen, Jine,Zhang, Changpeng,Xu, Zhenlan,Li, Gang,Cai, Leiming,Shen, Weifeng,Wang, Qiang. 2018

[14]Genomic structure, polymorphism and expression analysis of growth hormone-releasing hormone and pituitary adenylate cyclase activating polypeptide genes in the half-smooth tongue sole (Cynoglossus semilaevis). Ma, Q.,Liu, S. F.,Zhuang, Z. M.,Lin, L.,Sun, Z. Z.,Liu, C. L.,Tang, Q. S.,Ma, Q.,Lin, L.,Su, Y. Q.. 2011

[15]Molecular Analysis of a Selenoprotein M Gene from Penaeus monodon and its Expression at Different Ovarian Stages of Development. Zhou, FaLin,Qiu, Lihua,Huang, JianHua,Yang, QiBin,Fu, Mingjun,Jiang, ShiGui,Zhou, FaLin,Qiu, Lihua,Huang, JianHua,Yang, QiBin,Fu, Mingjun,Jiang, ShiGui. 2015

[16]Two Delta 6-desaturase-like genes in common carp (Cyprinus carpio var. Jian): Structure characterization, mRNA expression, temperature and nutritional regulation. Ren, Hong-tao,Yu, Ju-hua,Xu, Pao,Ren, Hong-tao,Zhang, Guang-qin,Li, Jian-lin,Tang, Yong-kai,Li, Hong-xia,Yu, Ju-hua,Xu, Pao. 2013

[17]Lipopolysaccharide and beta-1,3-glucan binding protein in the hard clam (Meretrix meretrix): Molecular characterization and expression analysis. Liu, S. X.,Zhang, J. J.,Li, H. J.,Qi, Z. H.,He, C. B.,Gao, X. G.. 2014

[18]Identification of Four ATP-Binding Cassette Transporter Genes in Cnaphalocrocis medinalis and Their Expression in Response to Insecticide Treatment. Yu, Hai-Zhong,Xu, Jia-Ping,Wang, Xue-Yang,Ma, Yan,Yu, Dong,Fei, Dong-Qiong,Zhang, Shang-Zhi,Wang, Wan-Ling. 2017

[19]Molecular cloning, characterization and mRNA expression of a ryanodine receptor gene from whitefly, Bemisia tabaci MED. Zhang, Wei,Qu, Cheng,Li, Fengqi,Luo, Chen,Wang, Ran,Mu, Changqing,Wang, Jinda. 2017

[20]A novel serine protease with clip domain from scallop Chlamys farreri. Zhu, Ling,Song, Linsheng,Zhao, Jiangmin,Li, Chenghua,Xu, Wei,Zhu, Ling,Mao, Yuze. 2008

作者其他论文 更多>>

微信小程序