Wip1-dependent modulation of macrophage migration and phagocytosis

文献类型： 外文期刊

第一作者： Tang, Yiting

作者： Tang, Yiting;Gao, Qian;Huang, Lei;Xia, Ying;Yang, Shulin;Mu, Yulian;Li, Kui;Pan, Bing;Pan, Bing;Pan, Bing;Zhou, Xin;Xu, Xuehong;Xiong, Kai;Shen, Ming;Liu, Honglin;Tan, Tao;Ma, Jianjie

作者机构：

期刊名称：REDOX BIOLOGY （ 影响因子：11.799； 五年影响因子：12.038 ）

ISSN： 2213-2317

年卷期： 2017 年 13 卷

页码：

收录情况： SCI

摘要： Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atherosclerotic diseases. Here, we show that Wip1, a member of the PP2C family of Ser/Thr protein phosphatases, modulates macrophage migration and phagocytosis associated with atherosclerotic plaque formation. Wip1 deficiency increases migratory and phagocytic activities of the macrophage under stress conditions. Enhanced migration of Wip1(-/-) macrophages is mediated by Racl-GTPase and PI3IC/AKT signalling pathways. Elevated phagocytic ability of Wip1(-/-) macrophages is linked to CD36 plasma membrane recruitment that is regulated by AMPK activity. Our study identifies Wip1 as an intrinsic negative regulator of macrophage chemotaxis. We propose that Wip1-dependent control of macrophage function may provide avenues for preventing or eliminating plaque formation in atherosclerosis.

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