A meta-analysis of transcriptomic characterization revealed extracellular matrix pathway involved in the H5N1 and H7N9 infections

文献类型: 外文期刊

第一作者: Wen, Feng

作者: Wen, Feng;Tong, Guangzhi;Wang, Qi;Liu, Xiaomin;Wang, Shuaiyong;Shan, Tonglin;Tong, Wu;Zhou, Yanjun;Li, Guoxin;Yu, Hai;Guo, Jinyue;Bi, Dingren;Tong, Guangzhi;Yu, Hai

作者机构:

关键词: influenza A;H7N9;H5N1;meta-analysis;extracellular matrix

期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )

ISSN: 1949-2553

年卷期: 2017 年 8 卷 37 期

页码:

收录情况: SCI

摘要: Avian-origin H5N1 and H7N9 influenza A viruses are capable of causing lethal infection in humans, with serious lung pathology and leading to acute respiratory distress syndrome. The contribution of host response associated with the poor prognosis of H5N1 and H7N9 infections remains unclear. The aim of this study was to identify the host factors involved in the high pathogenicity of H5N1 and H7N9 by a systematical meta-analysis. The RNA-seq datasets related to H5N1, H7N9, and H1N1 infections with time series were retrieved from GEO. After merging the data from different series, ComBat was used to adjust the known variances from different batches. The transcription factors binding the genes in each cluster were predicted by PASTAA. We figured out the genes that were differentially expressed at any time point in samples infected with H5N1, H7N9, or H1N1. The analysis of biological function showed that genes related with cytokine were up-regulated in all three viruses. However, genes associated with carbon metabolism were found exclusively down-regulated in H7N9 and the extracellular matrix pathway were only enriched in H5N1 and H7N9. To summary, our study suggested that the extracellular matrix might be associated with the high fatality of H5N1 and H7N9 viruses in humans.

分类号:

  • 相关文献

[1]Generation and application of replication-competent Venus-expressing H5N1, H7N9, and H9N2 influenza A viruses. Wang, Guangwen,Zhang, Jie,Kong, Fandi,Li, Qibing,Wang, Jinliang,Ma, Shujie,Zhao, Yuhui,Liang, Libin,Li, Junping,Sun, Nan,Guan, Lizheng,Zhou, Yuan,Zhou, Chenchen,Huang, Shanyu,Bu, Zhigao,Jiang, Li,Chen, Hualan,Li, Chengjun. 2018

[2]Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Zhou, Zhen,Li, Xihan,Dong, Lei,Chen, Qun,Liu, Jialing,Hou, Dongxia,Zhang, Lin,Liu, Yuchen,Zhang, Yujing,Li, Jing,Wang, Jin,Chen, Xi,Zhang, Junfeng,Zen, Ke,Zhang, Chen-Yu,Liu, Jinxiong,Kong, Huihui,Zhang, Qianyi,Zhang, Guoquan,Qi, Xian,Wang, Hua. 2015

[3]Histological and Ultrastructural Observation Reveals Significant Cellular Differences between Agrobacterium Transformed Embryogenic and Non-embryogenic Calli of Cotton. Shang, Hai-Hong,Liu, Chuan-Liang,Zhang, Chao-Jun,Li, Feng-Lian,Hong, Wei-Dong,Li, Fu-Guang.

[4]Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses. Wang Xiu-rong,Gu Lin-lin,Shi Jian-zhong,Xu Hai-feng,Zhang Ying,Zeng Xian-ying,Deng Guo-hua,Li Cheng-jun,Chen Hua-lan. 2017

[5]Pathogenesis and Phylogenetic Analyses of Two Avian Influenza H7N1 Viruses Isolated from Wild Birds. Jin, Hongmei,Sun, Jing,Chen, Guang,Zhang, Xiaolin,Zhang, Jiajie,Li, Xiang,Chai, Hongliang,Hua, Yuping,Wang, Deli,Cui, Yanfang,Li, Yanbing,Sun, Jing,Chen, Guang,Gao, Yuwei. 2016

[6]Isolation and characterization of H7N9 viruses from live poultry markets-Implication of the source of current H7N9 infection in humans. Shi JianZhong,Deng GuoHua,Guan LiZheng,Li WenHui,Li XuYong,Guo Jing,Wang GuoJun,Fan Jun,Wang JinLiang,Li YuanYuan,Jiang YongPing,Liu LiLing,Tian GuoBin,Li ChengJun,Chen HuaLan,Liu PeiHong,Zhou JinPing. 2013

[7]Phylogenetic Analysis and Pathogenicity Assessment of Two Strains of Avian Influenza Virus Subtype H9N2 Isolated from Migratory Birds:High Homology of Internal Genes with Human H10N8 Virus. Ye, Ge,Liang, Chai Hong,Ping, Hua Yu,Hua, Deng Guo,Lan, Chen Hua,Song, Lei Yong,Xiang, Yang Guo,Guang, Chen. 2016

[8]H7N9 avian influenza A virus in China: a short report on its circulation, drug resistant mutants and novel antiviral drugs. Bao Danqi,Li, Zejun,Liu, Qinfang,Bao Danqi,Richt, Juergen A..

[9]H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Shi, Jianzhong,Deng, Guohua,Kong, Huihui,Gu, Chunyang,Ma, Shujie,Yin, Xin,Zeng, Xianying,Cui, Pengfei,Chen, Yan,Yang, Huanliang,Wan, Xiaopeng,Wang, Xiurong,Liu, Liling,Chen, Pucheng,Jiang, Yongping,Liu, Jinxiong,Guan, Yuntao,Li, Mei,Qu, Zhiyuan,Guan, Lizheng,Zang, Jinkai,Gu, Wenli,Han, Shuyu,Song, Yangming,Hu, Yuzhen,Wang, Zeng,Gu, Linlin,Yang, Wenyu,Liang, Libin,Bao, Hongmei,Tian, Guobin,Li, Yanbing,Qiao, Chuanling,Jiang, Li,Li, Chengjun,Bu, Zhigao,Chen, Hualan,Suzuki, Yasuo. 2017

[10]Detection of Avian H7N9 Influenza A Viruses in the Yangtze Delta Region of China During Early H7N9 Outbreaks. Li, Yin,Huang, Xin-Mei,Zhao, Dong-Min,Liu, Yu-Zhuo,He, Kong-Wang,Xie, Xing-Xing,Han, Kai-Kai,Liu, Xiao-Yan,Yang, Jing,Li, Yin,Huang, Xin-Mei,Zhao, Dong-Min,Liu, Yu-Zhuo,He, Kong-Wang,Xie, Xing-Xing,Han, Kai-Kai,Liu, Xiao-Yan,Yang, Jing,Liu, Yao-Xing,Chen, Chang-Hai,Long, Li-Ping,Xu, Yifei,Wan, Xiu-Feng,Zhang, You-Fa,Fan, Feng,Webby, Richard.

[11]H5N1 avian influenza in China. Chen HuaLan,Chen HuaLan. 2009

[12]Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Leung, Bo Wah,Brownlee, George G.,Chen, Hualan. 2010

[13]A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge. Liu, Guangliang,Zhang, Fangfang,Shi, Jianzhong,Tian, Guobing,Chen, Hualan,Yu, Kangzheng,Meng, Qingwen. 2013

[14]Expression of an Avian Influenza Virus (H5N1) Hemagglutinin Gene in Transgenic Lotus corniculatus. Guo, Qian-Qian,Zhang, Zhan-Lu,Jiang, San-Jie,Ma, Jiang-Tao,Wu, Yan-Min,Zhang, Zhan-Lu,Xue, Wen-Tong,Ma, Jiang-Tao.

[15]Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice. Shi, Jianzhong,Wen, Zhiyuan,Guo, Jing,Zhang, Ying,Deng, Guohua,Jiang, Yongping,Bu, Zhigao,Chen, Hualan,Shu, Yuelong,Wang, Dayan,Kawaoka, Yoshihiro.

[16]Avian influenza vaccines against H5N1 'bird flu'. Li, Chengjun,Bu, Zhigao,Chen, Hualan.

[17]Detection prevalence of H5N1 avian influenza virus among stray cats in eastern China. Zhao, Fu-Rong,Zhou, Dong-Hui,Zhang, Yong-Guang,Shao, Jun-Jun,Lin, Tong,Li, Yang-Fan,Wei, Ping,Chang, Hui-Yun,Zhao, Fu-Rong,Zhou, Dong-Hui,Zhang, Yong-Guang,Shao, Jun-Jun,Lin, Tong,Li, Yang-Fan,Wei, Ping,Chang, Hui-Yun,Wei, Ping.

[18]Changes in methylation of genomic DNA from chicken immune organs in response to H5N1 influenza virus infection. Zhang, Y. H.,Meng, J. L.,Gao, Y.,Zhang, J. Y.,Niu, S. L.,Sun, B. X.,Zhao, Z. H.,Yu, X. Z.,Li, Y. B.,Guan, Y. T.. 2016

[19]Evaluation of Specific Pathogen-Free Ducks Infected with the Highly Pathogenic Avian Influenza Virus H5N1 Subtype Derived from Wild Birds. Guan, Xueting,Chai, Hongliang,Wang, Yulong,Hua, Yuping,Li, Yanbing,Liu, Jingli,Guan, Xueting. 2014

[20]Host cell interactome of PA protein of H5N1 influenza A virus in chicken cells. Wang, Qiao,Li, Qinghe,Liu, Ranran,Zheng, Maiqing,Wen, Jie,Zhao, Guiping.

作者其他论文 更多>>