Antiviral activity of arctigenin against Chinese rice-field eel rhabdovirus in Monopterus albus

文献类型： 外文期刊

第一作者： Liu, Yisha

作者： Liu, Yisha;Xue, Mingyang;Xu, Chen;Zhou, Yong;Jiang, Nan;Meng, Yan;Li, Yiqun;Huang, Zhenyu;Liu, Wenzhi;Li, Zhong;Fan, Yuding;Liu, Yisha;Zhong, Qiwang

作者机构：

关键词： Arctigenin; Rhabdovirus; Monopterus albus; Antiviral

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）

ISSN： 0044-8486

年卷期： 2025 年 595 卷

页码：

收录情况： SCI

摘要： Chinese rice-field eel rhabdovirus (CrERV) causes serious disease and leads to heavy economic losses in Chinese rice-field eel farming industry. There is currently no established treatment strategy for CrERV. We evaluated the antiviral properties of 8 natural compounds against CrERV using Gibel carp brain (GiCB) cells. Among these compounds, arctigenin showed substantial inhibition of CrERV replication, reaching the highest inhibition rate of 63.90 +/- 3.93 % at 2 mg/L in GiCB cells. Arctigenin preserved the normal morphology of CrERV-infected cells, reduced the intracellular nuclear damage, and disrupted CrERV infection by interfering with viral attachment and entry. Time of addition studies suggested that arctigenin might exert its antiviral effect during the initial phase of virus replication. In vivo experiments demonstrated a significant 33.33 % increase in the survival rate of Chinese rice-field eel upon arctigenin administration. In summary, arctigenin has been verified as a natural substance possessing exceptional anti-CrERV activity, showing promise for potential use in aquaculture treatment of CrERV.

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