Plasma pharmacokinetics of melamine and a blend of melamine and cyanuric acid in rainbow trout (Oncorhynchus mykiss)

文献类型： 外文期刊

第一作者： Xue, Min

作者： Xue, Min;Qin, Yuchang;Wang, Jia;Wu, Xiufeng;Zheng, Yinhua;Wang, Qiuyan;Xue, Min;Qiu, Jing

作者机构：

关键词： Oncorhynchus mykiss;Pharmacokinetics;Melamine;Cyanuric acid;Plasma

期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY （ 影响因子：3.271； 五年影响因子：4.291 ）

ISSN： 0273-2300

年卷期： 2011 年 61 卷 1 期

页码：

收录情况： SCI

摘要： The objective of the study was to obtain pharmacokinetic parameters for melamine and blend of melamine (MEL) and cyanuric acid (CYA) in rainbow trout (Oncorhynchus mykiss). The single target dosage of MEL (20 mg/kg bw) and the blend of MEL and CYA (5 and 1.67 mg/kg bw, respectively) were designed and plasma samples were collected at 30 min, 1, 4, 8, 12, 20, 24, 36, 48, 72, 144 and 240 h sequentially. An optimized method for simultaneous determination of MEL and CYA in plasma and animal tissues by LC-MS/MS was used. The data were shown to best fit a non-compartment model with first order processes of linear characters for melamine, with half-life (t(1/2)) of 32.2-32.9 h, clearance (Cl(z/F)) of 35.9-36.6 ml/h/kg, and volume of distribution (V(ss)) of 1.67-1.74 l/kg. Withdrawal of CYA was much more rapid than that of MEL with higher Cl(z/F) (783.56 ml/h/kg) and shorter t(1/2) (7.92 h). T(max) of MEL20 and MEL5 were 12 and 20 h, respectively, which showed that T(max) of MEL5 was delayed when MEL and CYA were given together. The results are quite different from those in mammals and showed much slower elimination of MEL and CYA from rainbow trout body. (C) 2011 Elsevier Inc. All rights reserved.

分类号：

  • 相关文献

[1]Tissue Deposition and Residue Depletion in Lambs Exposed to Melamine and Cyanuric Acid-Contaminated Diets. Lv, Xiaowen,Wu, Lei,Li, Junguo,Wu, Zilin,Qin, Yuchang,Lv, Xiaowen,Wang, Jing,Qiu, Jing. 2010

[2]Tissue deposition and residue depletion in rainbow trout following continuous voluntary feeding with various levels of melamine or a blend of melamine and cyanuric acid. Liu, Haiyan,Xue, Min,Wang, Jia,Wu, Xiufeng,Zheng, Yinhua,Li, Junguo,Qin, Yuchang,Liu, Haiyan,Xue, Min,Qiu, Jing,Qin, Yuchang. 2014

[3]Pathway for the elimination of melamine in lactating dairy cows. Sun, P.,Wang, J. Q.,Shen, J. S.,Wei, H. Y.. 2012

[4]Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma. Yang, Yuhui,Zhang, Weihua,Liu, Yanhong.

[5]Liquid-Phase Synthesis of Cyanuric Acid from Urea. Li, Chun-Jiu,She, Dong-Mei,Yu, Hai-Lin,Huang, Qi-Liang,Li, Fen-Ming. 2010

[6]Analysis of Nutritional Components in Muscle of Different Strains of Rainbow Trout. Xue Shu-Qun,Sun Zhong-Wu,Xue Shu-Qun,Yin Hong-Bin. 2012

[7]Genomic heritability estimation for the early life-history transition related to propensity to migrate in wild rainbow and steelhead trout populations. Hu, Guo,Hu, Guo,Wang, Chunkao,Da, Yang. 2014

[8]Effects of heat stress on serum cortisol, alkaline phosphatase activity and heat shock protein 40 and 90 beta mRNA expression in rainbow trout Oncorhynchus mykiss. Li, Zhen,Liu, Zhe,Wang, Yan Ni,Kang, Yu Jun,Wang, Jian Fu,Shi, Hai Na,Huang, Jin Qiang,Jiang, Li.

[9]Effects of heat stress on respiratory burst, oxidative damage and SERPINH1 (HSP47) mRNA expression in rainbow trout Oncorhynchus mykiss. Wang, Yanni,Liu, Zhe,Li, Zhen,Shi, Haina,Kang, Yujun,Wang, Jianfu,Huang, Jinqiang,Jiang, Li.

[10]Comparative blood biochemistry of Amur sturgeon, Acipenser schrenckii, and Chinese surgeon, Acipenser sinensis. Shi, Xiaotao,Li, Dapeng,Zhuang, Ping,Nie, Fen,Long, Liangqi. 2006

[11]Simultaneous Detection of 21 Kinds of Mycotoxins and Their Metabolites in Animal Plasma with Impurity Adsorption Purification Followed by Liquid Chromatography-Tandem Mass Spectrometry. Wang Rui-Guo,Su Xiao-Ou,Wang Pei-Long,Zhang Wei,Xue Yan,Li Yu. 2017

[12]Effect of supplemental beta-carotene in the periparturient diet on plasma vitamin A and beta-carotene concentrations and lymphocyte proliferation in Holstein cows. He, W. J.,Ren, L. P.,Meng, Q. X.,He, W. J.,Ren, L. P.,Meng, Q. X.,Zhang, Q. D.. 2007

[13]Comparative Proteomic Analysis of Plasma from Clinical Healthy Cows and Mastitic Cows. Yang Yong-xin,Zhao Xing-xu,Zhang Yong,Yang Yong-xin. 2009

[14]Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle. Tang, Chaohua,Zhang, Kai,Liang, Xiaowei,Zhao, Qingyu,Zhang, Junmin.

[15]Study on an antifouling and blood compatible poly(ethylene-vinyl acetate) material with fluorinated surface structure. Wen, Xiao-Wen,Pei, Su-Peng,Li, Hong,Ai, Fei,Chen, Huan,Zhang, Yong-Ming,Li, Ke-Yong,Wang, Quan.

[16]In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma. Zheng, Ming-Ming,Wang, Shao-Ting,Hu, Wei-Kang,Feng, Yu-Qi,Zheng, Ming-Ming.

[17]Non-thermal plasma assisted polymer surface modification and synthesis: A review. Cheng Yanling,Cheng Yanling,Chen, Paul,Deng, Shaobo,Ruan, Roger,Wang Yingkuan. 2014

[18]ITRAQ quantitative analysis of plasma proteome changes of cow from pregnancy to lactation. Ma Lu,Yan Su-mei,Ma Lu,Bu Deng-pan,Yang Yong-xing,Wang Jia-qi,Bu Deng-pan. 2015

[19]Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis. Zhang, Weidong,Zhao, Yong,Li, Lan,Feng, Yanni,Min, Lingjiang,Ma, Dongxue,Yu, Shuai,Shen, Wei,Zhao, Yong,Zhang, Hongfu,Li, Fuli,Liu, Jing,Shi, Tianhong,Li, Fuwei. 2018

[20]Isobaric Tags for Relative and Absolute Quantification (iTRAQ)-Based Untargeted Quantitative Proteomic Approach To Identify Change of the Plasma Proteins by Salbutamol Abuse in Beef Cattle. Zhang, Kai,Tang, Chaohua,Liang, Xiaowei,Zhao, Qingyu,Zhang, Junmin,Zhang, Kai,Tang, Chaohua,Liang, Xiaowei,Zhao, Qingyu,Zhang, Junmin. 2018

作者其他论文 更多>>

微信小程序