Generation of a recombinant rabies Flury LEP virus carrying an additional G gene creates an improved seed virus for inactivated vaccine production
文献类型: 外文期刊
第一作者: Tao, Lihong
作者: Tao, Lihong;Ge, Jinying;Wang, Xijun;Wen, Zhiyuan;Zhai, Hongyue;Hua, Tao;Zhao, Bolin;Kong, Dongni;Bu, Zhigao;Yang, Chinglai
作者机构:
关键词: Rabies virus;LEP;recombinant;inactivated vaccine
期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )
ISSN: 1743-422X
年卷期: 2011 年 8 卷
页码:
收录情况: SCI
摘要: The rabies Flury Low Egg Passage virus (LEP) has been widely used as a seed virus to generate inactive vaccine. Here, we established a reverse genetic system for LEP and generated a recombinant LEP virus (rLEP-G) that carries two identical G genes. This recombinant virus showed similar properties to those of LEP with respect to in vitro growth, neurotropism index, and virulence in mice. rLEP-G produced 4.3-fold more G protein than did LEP in BHK-21 cells. The inactivated vaccine generated from rLEP-G induced significantly higher virus neutralization titers in mice and dogs than those produced in response to LEP-derived vaccine. Our results suggest that rLEP-G is an improved seed virus candidate for inactivated rabies virus vaccine manufacture.
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