Leucocytes DNA damage in mice exposed to JS-118 by the comet assay

文献类型： 外文期刊

第一作者： Zhao, Qianfei

作者： Zhao, Qianfei;Ning, Jun;Hu, Jiye;Zhang, Yuchao

作者机构：

关键词： JS-118;SCGE;genotoxicity;male Kunming mice;leucocytes

期刊名称：HUMAN & EXPERIMENTAL TOXICOLOGY （ 影响因子：2.903； 五年影响因子：2.712 ）

ISSN： 0960-3271

年卷期： 2011 年 30 卷 9 期

页码：

收录情况： SCI

摘要： JS-118 is an extensively used insecticide in China. The present study investigated the genotoxic effect of JS-118 on whole blood at 24, 48, 72 and 96 h by using alkaline comet assay. Male Kunming mice were given 6.25, 12.5, 25, 50 and 100 mg/kg BW of JS-118 intraperitoneally. A statistically significant increase in all comet parameters indicating DNA damage was observed at 24 h post-treatment (p < 0.05). A clear concentration-dependent increase of DNA damage was revealed as evident by the OTM (arbitrary units), tail length (mm) and tail DNA (%). From 48 h post-treatment, a gradual decrease in mean comet parameters was noted. By 96 h of post-treatment, the mean comet tail length reached control levels indicating repair of damaged DNA. This study on mice showed different DNA damage depending on the concentration of JS-118 and the period of treatment. The present study provided further information of the potential risk of the genetic damage caused by JS-118.

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