Novel Rapid Molecular Modeling Method Based on Evolutional Tree for Human Adenovirus Hexon Proteins Family

文献类型： 外文期刊

第一作者： Yuan Xiao-Hui

作者： Yuan Xiao-Hui;Wang Ying-Chen;Qu Zhang-Yi;Gao Hong;Yuan Xiao-Hui;Ren Jia-Yi;Yuan Xiao-Hui;Ren Jia-Yi;Ren Jia-Yi;Wang Ya-Xian;Hua Dong;Wang Jing-Fei;Guo Ying-Ying;Wu Xiao-Min;Yang Zhi-Wei

作者机构：

关键词： Homology modeling;Evolutional tree;Human Adenovirus(HAdV);Hexon proteins family

期刊名称：CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE （ 影响因子：0.65； 五年影响因子：0.481 ）

ISSN： 0251-0790

年卷期： 2011 年 32 卷 8 期

页码：

收录情况： SCI

摘要： Human adenoviruses( HAdVs ) are responsible for many infectious diseases. 54 different serotypes of HAdVs have been identified so far, and the diversity of HAdVs has brought some difficulties to clinical diagnosis and therapy. In this study, a novel rapid modeling method for proteins family was developed on the basis of evolutionary tree, and by this method 7 hexon homologous proteins from D sub-specie Human adenoviruses( HAdVs ) were modeled. An evolutionary tree of these 7 hexon protein amino acid sequences was constructed by neighbor-joining( NJ ) algorithm; based on the information from the evolutional tree, an optimal modeling route was determined to accelerate the modeling of these hexons; And then,. rapid modeling. of hexons was automatically completed using homology modeling method within MODELER and CHARMM program; and the sturcures were proved to be acceptable by two assessment methods. Compared with the traditional scheme, this novel method can significantly reduce the amount of calculation. Every hexon structure model produced by this novel rapid modelling method could be reliably superimposed to the corresponding model produced by the traditional method. The rapid modeling of HAdVs hexon protein is very important to the molecular designing of HAdVs vaccines and the development of rapid HAdVs diagnostic typing agents.

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