Genome-Wide Association Study of Body Weight in Chicken F2 Resource Population

文献类型： 外文期刊

第一作者： Gu, Xiaorong

作者： Gu, Xiaorong;Feng, Chungang;Song, Chi;Wang, Yanqiang;Hu, Xiaoxiang;Li, Ning;Ma, Li;Da, Yang;Song, Chi;Li, Huifang;Chen, Kuanwei;Ye, Shaohui;Ge, Changrong;Li, Ning

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2011 年 6 卷 7 期

页码：

收录情况： SCI

摘要： Chicken body weight is an economically important trait and great genetic progress has been accomplished in genetic selective for body weight. To identify genes and chromosome regions associated with body weight, we performed a genome-wide association study using the chicken 60 k SNP panel in a chicken F2 resource population derived from the cross between Silky Fowl and White Plymouth Rock. A total of 26 SNP effects involving 9 different SNP markers reached 5% Bonferroni genome-wide significance. A chicken chromosome 4 (GGA4) region approximately 8.6 Mb in length (71.6-80.2 Mb) had a large number of significant SNP effects for late growth during weeks 7-12. The LIM domain-binding factor 2 (LDB2) gene in this region had the strongest association with body weight for weeks 7-12 and with average daily gain for weeks 6-12. This GGA4 region was previously reported to contain body weight QTL. GGA1 and GGA18 had three SNP effects on body weight with genome-wide significance. Some of the SNP effects with the significance of "suggestive linkage" overlapped with previously reported results.

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