Expression and Prognostic Values of Id-1 and Id-3 in Gastric Adenocarcinoma

文献类型： 外文期刊

第一作者： Yang, Hai-Yan

作者： Yang, Hai-Yan;Liu, Lian-Xin;Jiang, Hong-Chi;Liu, Hao-Ling;Zhu, Hong;Liu, Gai-Yun;Meng, Qing-Wen;Qu, Lian-Dong

作者机构：

关键词： Id-1;Id-3;immunohistochemistry;Western blotting;expression;disregulation;clinical values;prognostic;3-year survival

期刊名称：JOURNAL OF SURGICAL RESEARCH （ 影响因子：2.192； 五年影响因子：2.442 ）

ISSN： 0022-4804

年卷期： 2011 年 167 卷 2 期

页码：

收录情况： SCI

摘要： Background. Id (inhibitor of differentiation/DNA binding)-1 and -3 are involved in neoangiogenesis; they antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. The aim of this study was to investigate Id-1 and -3 expression in gastric tumors and their clinical relevance in gastric cancer. Materials and Methods. We investigated Id-1 and Id-3 expression in gastric cancer samples by immunohistochemistry and Western blotting, and further analyzed the relationship between expression of Id-1 and Id-3 and clinicopathologic characteristics. Results. Expression of Id-1 and -3 was found significantly more often in gastric cancers than in matched adjacent nonmalignant tissues. Cancer samples with poor or moderate histologic differentiation showed significantly stronger Id-1 and -3 expression than cancer samples with high differentiation. In cancer samples, strong or moderate expression of Id-3, but not Id-1, was a strong independent predictor for shorter overall survival in multivariate analysis. Conclusions. The level of Id-1 and -3 protein expression was associated with the malignant potential of gastric tumors. In cancer samples, stronger Id-1 and -3 expression is associated with poor differentiation and more aggressive behavior of tumor cells, resulting in poor clinical outcome. Consequently, Id-3 might be used to independently predict survival of patients with gastric cancer. (C) 2011 Published by Elsevier Inc.

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