A QuEChERS method based on octadecyl-bonded hectorite for the determination of ten mycotoxins in yak ghee

文献类型： 外文期刊

第一作者： Wang, Jun

作者： Wang, Jun;Yang, Hai-yan;Fan, Jia-jia;Xu, Zi-Han;Pang, Zai-hui;Feng, Yuan;Wei, Na

作者机构：

关键词： QuEChERS; Mycotoxins; Hectorite; Clean-up material; Yak ghee

期刊名称：ANALYTICAL SCIENCES （ 影响因子：2.0； 五年影响因子：1.6 ）

ISSN： 0910-6340

年卷期： 2025 年 41 卷 1 期

页码：

收录情况： SCI

摘要： To develop a clean-up material suitable for high-fat food matrices for detecting mycotoxins in yak ghee, an octadecyl-bonded hectorite (Hectorite@NHCO(CH2)17CH3) was synthesized through multi-step chemical reactions. A modified QuEChERS-HPLC-MS/MS method for detecting ten mycotoxins in sesame oil in yak ghee was established using Hectorite@NHCO(CH2)17CH3 as clean-up agent. It involved extracting mycotoxin contaminants using acidified acetonitrile and employing the Hectorite@NHCO(CH2)17CH3 to remove interfering substances from the extract. The purified samples were then analyzed using HPLC-MS/MS. Within a linear range of 1.0-500 mu g/kg, there was a good linear relationship between the quantification ion peak area of the target analytes and the corresponding concentrations (R2 >= 0.9991). The limit of detection (LOD) ranged from 0.10 mu g/kg to 18.62 mu g/kg and the limit of quantitation (LOQ) ranged 0.32-62.07 mu g/kg. The recoveries at low, medium and high concentrations (25, 100 and 500 mu g/kg) ranged from 72.2% to 113.9%, with relative standard deviations (RSD) between 3.2% and 17.5%. The intra-day and inter-day precision met experimental requirements. The proposed method was characterized by a high accuracy and precision, and it could cater to the current demand for detecting ten mycotoxins in yak ghee.

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