Genetic Polymorphisms of the CACNA2D1 Gene and Their Association with Carcass and Meat Quality Traits in Cattle

文献类型： 外文期刊

第一作者： Hou, Guan-Yu

作者： Hou, Guan-Yu;Yuan, Zheng-Rong;Gao, Xue;Li, Jun-Ya;Gao, Hui-Jiang;Chen, Jin-Bao;Xu, Shang-Zhong;Hou, Guan-Yu

作者机构：

关键词： Cattle;CACNA2D1 gene;Carcass and meat quality traits;SNPs;Association analysis

期刊名称：BIOCHEMICAL GENETICS （ 影响因子：1.89； 五年影响因子：1.959 ）

ISSN： 0006-2928

年卷期： 2010 年 48 卷 9-10 期

页码：

收录情况： SCI

摘要： The objective of this study was to identify genetic polymorphisms of the CACNA2D1 gene and to analyze associations between SNPs and carcass and meat quality traits in cattle. Through PCR-RFLP and DNA sequencing methods, a new allelic variant corresponding to the A -> G mutation (aspartic to glycine amino acid replacement) of the bovine CACNA2D1 gene was detected. Two alleles and three genotypes (AA, AG, and GG) were defined. Genetic character indicated that the A526745G locus showed moderate polymorphism and was in Hardy-Weinberg equilibrium. Gene-specific SNP marker association analysis showed that the A526745G mutant was significantly associated with carcass weight, dressing percentage, meat percentage, and backfat thickness. The results add new evidence that CACNA2D1 is an important candidate gene for the selection of carcass and meat quality traits in the cattle industry.

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