Simultaneous Determination of Seven Mental Drugs in Feeds by Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Suo De-Cheng

作者： Suo De-Cheng;Zhao Gen-Long;Li Lan;Su Xiao-Ou

作者机构：

关键词： Liquid chromatography-tandem mass spectrometry;Feed;Mental drug

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）

ISSN： 0253-3820

年卷期： 2010 年 38 卷 7 期

页码：

收录情况： SCI

摘要： A method was established for the simultaneous determination of seven mental drugs by LC-MS/MS. In this method, the conditions of appropriate extracting solvent, SPE cartridge and LC-MS/MS were optimized. The drugs were extracted with acetonitrile/water (9:1, V/V), and then purified by MCX solid-phase extraction (SPE) column. The elution was evaporated by nitrogen blow, dissolved in acetonitrile/water( 2:8, V/V) and analyzed by LC-MS/MS. The limit of detection (LOD) was 1.0 ng/g of nitrazepam, oxazepam, promethazine and chlorpromazine, and 5.0 ng/g of diazepam, perphenazine; and thioridazine. The recoveries were 53.9% - 110.2%, and RSDs were 3.4% - 18.4%. Results showed that this developed method was very reliable for the determination of seven mental drugs in feeds.

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