Oxidized Chitosan-Tobramycin (OCS-TOB) Submicro-Fibers for Biomedical Applications

文献类型： 外文期刊

第一作者： Li, Zhen

作者： Li, Zhen;Dong, Yajie;She, Fenghua;Kong, Lingxue;Li, Zhen;Mei, Shunqi;Dong, Yajie;Li, Chengpeng;Li, Yongzhen

作者机构：

关键词： chitosan; tobramycin; centrifugal spinning; submicro-fibers; biomedical application

期刊名称：PHARMACEUTICS （ 影响因子：6.525； 五年影响因子：7.227 ）

ISSN：

年卷期： 2022 年 14 卷 6 期

页码：

收录情况： SCI

摘要： Chitosan (CS) is a biodegradable, biocompatible, and non-toxic natural amino-poly-saccharide with antibacterial ability, owing to its positively charged amino groups. However, the low charge density leads to poor antibacterial efficiency which cannot meet the biomedical application requirements. In this study, Tobramycin (TOB) was grafted onto the backbone of oxidized chitosan (OCS) to synthesize oxidized chitosan-tobramycin (OCS-TOB). FTIR, H-1 NMR and elemental analysis results demonstrated that OCS-TOB was successfully synthesized. OCS-TOB/PEO composite fibrous materials were produced by a self-made centrifugal spinning machine. In vitro experiments showed that cells proliferated on the submicro-fibrous OCS-TOB/PEO of appropriate concentration, and the antibacterial ability of OCS-TOB was much improved, compared with pristine CS. The results demonstrated that OCS-TOB/PEO nanofibrous materials could potentially be used for biomedical applications.

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