EFFECT OF THE ROUTE OF FOOT-AND-MOUTH DISEASE VIRUS INFECTION OF PIGLETS ON THE COURSE OF DISEASE

文献类型: 外文期刊

第一作者: Li, D.

作者: Li, D.;Bai, X. -W.;Sun, P.;Fu, Y. -F.;Xie, B. -X.;Lu, Z. -J.;Chen, Y. -L.;Cao, W. -J.;Liu, Z. -X.

作者机构:

关键词: Foot-and-mouth disease virus;challenge routes;intranasal drops;intradermal injection;intramuscular injection;pig

期刊名称:ACTA VIROLOGICA ( 影响因子:1.162; 五年影响因子:1.255 )

ISSN: 0001-723X

年卷期: 2010 年 54 卷 4 期

页码:

收录情况: SCI

摘要: Three different routes of Foot-and-mouth disease virus (FMDV) infection of piglets, namely intranasal (i.n.) through drops, intradermal (i.d.) into the foot, and intramuscular (i.m.) were compared regarding the onset and severity of the disease. The results showed that the id. injection of the virus resulted in the fastest onset of the disease. The i.m. injection led to a delayed onset, but the final effect was identical with i.d. injection. Moreover, the i.m. injection was simpler to perform and easier to evaluate. Therefore, the i.m. injection of piglets is recommended as the optimal infection route for evaluation of the FMDV vaccine potency.

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