Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

文献类型: 外文期刊

第一作者: Wen, Zhiyuan

作者: Wen, Zhiyuan;Ye, Ling;Gao, Yulong;Pan, Lei;Dong, Ke;Compans, Richard W.;Yang, Chinglai;Wen, Zhiyuan;Ye, Ling;Gao, Yulong;Pan, Lei;Dong, Ke;Compans, Richard W.;Yang, Chinglai;Wen, Zhiyuan;Gao, Yulong;Bu, Zhigao;Pan, Lei;Dong, Ke

作者机构:

关键词: Influenza;Virus-like particle;Aging;Antibody response;Avidity

期刊名称:ANTIVIRAL RESEARCH ( 影响因子:5.97; 五年影响因子:5.801 )

ISSN: 0166-3542

年卷期: 2009 年 84 卷 3 期

页码:

收录情况: SCI

摘要: Influenza virus-like particles (VLPs) were produced in Sf9 insect cells by co-expressing the matrix protein M1 and the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA) using the recombinant baculovirus expression system. The VLPs were morphologically similar to influenza virions. Both HA and NA proteins were incorporated into VLPs and these proteins retained their functional activities. Further, influenza VLPs but not inactivated influenza viruses (IIV) stimulated secretion of inflammatory cytokines from mouse bone marrow-derived dendritic cells (BMDC). Immunogenicity of influenza VLPs and their protective efficacies against lethal influenza virus challenge were evaluated in young and aged mice. Immunization with influenza VLPs induced strong antibody responses against HA that inhibited hemagglutination by influenza virus, similar to IIV vaccines. Compared to young mice, antibody responses in aged mice immunized with a low dose of either influenza VLPs or IIV vaccines exhibited markedly reduced avidity for HA. However, immunization of aged mice with a high dose of influenza VLPs induced antibody responses with high avidity similar to those in young mice. Furthermore, all vaccinated animals survived a lethal challenge by a mouse-adapted influenza virus (A/PR/8/34), indicating that influenza VLPs are highly efficacious for protection against influenza virus infection in both young and aged mice. (C) 2009 Elsevier B.V. All rights reserved.

分类号:

  • 相关文献

[1]Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice. Wen, Zhiyuan,Bu, Zhigao,Wang, Xi,Dong, Ke,Zhang, Huizhong,Wang, Xi,Dong, Ke,Zhang, Huizhong,Wen, Zhiyuan,Wang, Xi,Dong, Ke,Ye, Ling,Yang, Chinglai. 2017

[2]Function of VP2 Protein in the Stability of the Secondary Structure of Virus-like Particles of Genogroup II Norovirus at Different pH Levels: Function of VP2 Protein in the Stability of NoV VLPs. Yao Lin,Li Fengling,Wang Lianzhu,Zhai Yuxiu,Jiang Yanhua. 2014

[3]Self-assembly of virus-like particles of rabbit hemorrhagic disease virus capsid protein expressed in Escherichia coli and their immunogenicity in rabbits. Guo, Huimin,Zhu, Jie,Tan, Yonggui,Li, Chuanfeng,Chen, Zongyan,Liu, Guangqing,Sun, Shiqi.

[4]Newcastle disease virus-like particles induce dendritic cell maturation and enhance viral-specific immune response. Qian, Jing,Ding, Jiaxin,Yin, Renfu,Xue, Cong,Xu, Xiaohong,Cong, Yanlong,Ding, Zhuang,Qian, Jing,Ding, Jiaxin,Yin, Renfu,Xue, Cong,Xu, Xiaohong,Cong, Yanlong,Ding, Zhuang,Sun, Yixue,Wang, Jianzhong,Ding, Chan,Yu, Shengqing,Liu, Xiufan,Hu, Shunlin.

[5]Generation and characterization of a new mammalian cell line continuously expressing virus-like particles of Japanese encephalitis virus for a subunit vaccine candidate. Hua, Rong-Hong,Li, Ye-Nan,Chen, Zhen-Shi,Liu, Li-Ke,Huo, Hong,Wang, Xiao-Lei,Guo, Li-Ping,Shen, Nan,Wang, Jing-Fei,Bu, Zhi-Gao. 2014

[6]Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice. Gai, Weiwei,Zhang, Weijiao,Qiu, Boning,Gai, Weiwei,Wang, Hualei,Zhao, Yongkun,Wang, Qi,Zhang, Weijiao,Feng, Na,Qiu, Boning,Chi, Hang,Li, Nan,Wang, Tiecheng,Gao, Yuwei,Yang, Songtao,Xia, Xianzhu,Zheng, Xuexing,Wang, Chong,Wang, Qi,Wong, Gary,Shan, Junjie,Shan, Junjie,Yang, Songtao,Xia, Xianzhu. 2017

[7]Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV. Wang, Yong-shan,Ouyang, Wei,Liu, Xiao-juan,He, Kong-wang,Liu, Xiao-juan,Zhang, Hai-bin,Fan, Hong-jie,Lu, Cheng-ping,Yu, Sheng-qing. 2012

[8]Chimeric rabies glycoprotein with a transmembrane domain and cytoplasmic tail from Newcastle disease virus fusion protein incorporates into the Newcastle disease virion at reduced levels. Yu, Gui Mei,Zu, Shu Long,Zhou, Wei Wei,Wang, Xi Jun,Shuai, Lei,Wang, Xue Lian,Ge, Jin Ying,Bu, Zhi Gao. 2017

[9]Genome-wide association study of antibody response to Newcastle disease virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Hu, Xiaoxiang,Shu, Dingming. 2013

[10]Association of SNPs in exon 2 of the MHC B-F gene with immune traits in two distinct chicken populations: Chinese Beijing-You and White Leghorn. Liu, L. B.,Wu, C. M.,Wen, J.,Chen, J. L.,Zheng, M. Q.,Zhao, G. P..

[11]Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Wang, Gang,Song, Tengfei,Liu, Yonggang,Shi, Wenda,Wang, Shujie,Rong, Fulong,Dong, Jianguo,Liu, He,Cai, Xuehui,Wang, Gang,Song, Tengfei,Yu, Ying,Zhou, En-Min,Zhou, En-Min.

[12]Babesia gibsoni: An apical membrane antigen-1 homologue and its antibody response in the infected dogs. Zhou, Jinlin,Yang, Jun,Zhang, Guohong,Nishikawa, Yoshifumi,Fujisaki, Kozo,Xuan, Xuenan. 2006

[13]A 38-kDa protein from Babesia gibsoni and its antibody response in an experimentally infected dog. Zhou, Jinlin,Zhang, Guohong,Nishikawa, Yoshifumi,Fujisaki, Kozo,Xuan, Xuenan. 2006

[14]Chinese border disease virus strain JSLS12-01 infects piglets and down-regulates the antibody responses of classical swine fever virus C strain vaccination. Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Liu, Xia,Deng, Jiawu,Wei, Jianzhong.

[15]High genetic and antigenic similarity between a swine H3N2 influenza A virus and a prior human influenza vaccine virus: A possible immune pressure-driven cross-species transmission. Pan, Chungen,Jiang, Shibo,Wang, Guiping,Liao, Ming,Zhang, Gui-Hong. 2009

[16]Detection of influenza viral gene in European starlings and experimental infection. Qin, Zhuoming,Clements, Teresa,Wang, Leyi,Khatri, Mahesh,Pillai, Smitha P. S.,LeJeune, Jeffrey T.,Lee, Chang-Won,Qin, Zhuoming,Zhang, Yan,LeJeune, Jeffrey T.,Lee, Chang-Won. 2011

[17]The influenza virus gene pool in a poultry market in South Central China. Liu, M,He, SQ,Walker, D,Zhou, NN,Perez, DR,Mo, B,Li, F,Huang, XT,Webster, RG,Webby, RJ. 2003

[18]Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice. Shi, Jianzhong,Wen, Zhiyuan,Guo, Jing,Zhang, Ying,Deng, Guohua,Jiang, Yongping,Bu, Zhigao,Chen, Hualan,Shu, Yuelong,Wang, Dayan,Kawaoka, Yoshihiro.

[19]Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge. Nagy, Abdou,Lee, Jinhwa,Henningson, Jamie,Li, Yuhao,Ma, Jingjiao,Duff, Michael,Li, Yonghai,Lang, Yuekun,Yang, Jianmei,Richt, Juergen,Ma, Wenjun,Nagy, Abdou,Abdallah, Fatma,Ali, Ahmed,Mena, Ignacio,Garcia-Sastre, Adolfo,Mena, Ignacio,Garcia-Sastre, Adolfo,Yang, Jianmei,Garcia-Sastre, Adolfo.

[20]Fusion of C3d with hemagglutinin enhances protective immunity against swine influenza virus. Li, Guo-Xin,Tian, Zhi-Jun,Yu, Hai,Jin, Yuan-Yuan,Hou, Shao-Hua,Zhou, Yan-Jun,Liu, Tian-Qiang,Hu, Shou-Ping,Tong, Guang-Zhi,Li, Guo-Xin,Tong, Guang-Zhi,Li, Guo-Xin,Yu, Hai,Zhou, Yan-Jun,Tong, Guang-Zhi.

作者其他论文 更多>>