Bactrian camel (Camelus bactrianus) integrins alpha v beta 3 and alpha v beta 6 as FMDV receptors: Molecular cloning, sequence analysis and comparison with other species

文献类型： 外文期刊

第一作者： Du, Junzheng

作者： Du, Junzheng;Gao, Shandian;Chang, Huiyun;Cong, Guozheng;Lin, Tong;Shao, Junjun;Liu, Zaixin;Liu, Xiangtao;Cai, Xuepeng

作者机构：

关键词： Bactrian camel;FMDV receptors;Integrin alpha v family;Molecular characteristics;Phylogenetic tree;Tropism

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2009 年 131 卷 3-4 期

页码：

收录情况： SCI

摘要： Integrins are heterodimeric adhesion receptors that participate in a variety of cell-cell and cell-extracellular matrix protein interactions. Many integrins recognize RGD sequences displayed on extracellular matrix proteins and the exposed loops of viral capsid proteins. Four members of the alpha v integrin family of cellular receptors, alpha v beta 3, alpha v beta 6, alpha v beta 1 and alpha v beta 8, have been identified as receptors for foot-and-mouth disease virus (FMDV) in vitro, and integrins are believed to be the receptors used to target epithelial cells in the infected animals. To analyse the roles of the alpha v integrins from a susceptible species as viral receptors, we have cloned Bactrian camel alpha v, beta 3 and beta 6 integrin cDNAs and compared them to those of other species. The coding sequences for Bactrian camel integrin alpha v, beta 3 and beta 6 were found to be 3165, 2289 and 2367 nucleotides in length, encoding 1054, 762 and 788 amino acids, respectively. The Bactrian camel alpha v, beta 3 and beta 6 subunits share many structural features with homologues of other species, including the ligand binding domain and cysteine-rich region. Phylogenetic trees and similarity analyses showed the close relationships of integrin genes from Bactrian camels, pigs and cattle, which are each susceptible to FMDV infection, that were distinct from the orders Rodentia, Primates, Perissodactyla, Carnivora, Galliformes and Xenopus. We postulate that host tropism of FMDV may in part be related to the divergence in integrin subunits among different species. (C) 2009 Elsevier B.V. All rights reserved.

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