Toll-Like Receptor 2 Gene Polymorphism and its Relationship with SCS in Dairy Cattle

文献类型： 外文期刊

第一作者： Zhang, L. P.

作者： Zhang, L. P.;Li, H. D.;Li, J. Y.;Gao, X.;Chen, J. B.;Ren, H. Y.;Xu, S. Z.;Gan, Q. F.;Wang, X. P.;Xu, S. Z.;Ma, T. H.

作者机构：

关键词： Dairy cattle;Mastitis;TLR2

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

年卷期： 2009 年 20 卷 3 期

页码：

收录情况： SCI

摘要： Toll-like receptor 2 (TLR2) plays an important role in the innate immune response to a variety of pathogens. In this study, bovine TLR2 gene was taken as a candidate gene for mastitis resistance. Through PCR-SSCP analysis and sequencing, three missense mutations at T385G, G398A, and G1884A were detected in the coding region that encoded extracellular domain. Altogether 240 dairy cattle of three breeds (Holstein, Simmental, and Sanhe cattle) were genotyped and allele frequencies were determined. The effects of TLR2 polymorphisms on somatic cell score (SCS) were analyzed and significant association was found between T385G and SCS. The mean of genotype GG was significantly lower than those of genotype TT and TG. No significant associations were found with SCS for G398A and G1884A. Information provided in this research will be useful in further studies to determine the role of TLR2 gene in the mastitis resistance.

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